Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp 120454

被引：15
作者：
Bo, Sheng Tao [1 ]
Xu, Zi Fei [1 ]
Yang, Li [1 ]
Cheng, Ping [1 ]
Tan, Ren Xiang [1 ]
Jiao, Rui Hua [1 ]
Ge, Hui Ming [1 ]
机构：
[1] Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 06期
关键词：
GENE-CLUSTER; JADOMYCIN BIOSYNTHESIS; GLYCOSIDES; EXPRESSION; CLONING;
D O I：
10.1038/s41429-018-0039-x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B.
引用
收藏
页码：601 / 605
页数：5
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