Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp 120454

被引：15
作者：
Bo, Sheng Tao [1 ]
Xu, Zi Fei [1 ]
Yang, Li [1 ]
Cheng, Ping [1 ]
Tan, Ren Xiang [1 ]
Jiao, Rui Hua [1 ]
Ge, Hui Ming [1 ]
机构：
[1] Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 06期
关键词：
GENE-CLUSTER; JADOMYCIN BIOSYNTHESIS; GLYCOSIDES; EXPRESSION; CLONING;
D O I：
10.1038/s41429-018-0039-x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B.
引用
收藏
页码：601 / 605
页数：5
相关论文
共 50 条
  • [21] Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces
    Yan, Yijun
    Ma, Ya-Tuan
    Yang, Jing
    Horsman, Geoff P.
    Luo, Dan
    Ji, Xu
    Huang, Sheng-Xiong
    ORGANIC LETTERS, 2016, 18 (06) : 1254 - 1257
  • [22] Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis
    Ames, Brian D.
    Chi Nguyen
    Bruegger, Joel
    Smith, Peter
    Xu, Wei
    Ma, Suzanne
    Wong, Emily
    Wong, Steven
    Xie, Xinkai
    Li, Jesse W. -H.
    Vederas, John C.
    Tang, Yi
    Tsai, Shiou-Chuan
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (28) : 11144 - 11149
  • [23] Functional characterization of a novel violacein biosynthesis operon from Janthinobacterium sp. B9-8
    Xu, Xian
    Chu, Xiaoting
    Du, Bangmian
    Huang, Chunyan
    Xie, Chengjia
    Zhang, Zhidong
    Jiang, Ling
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2022, 106 (08) : 2903 - 2916
  • [24] Genome mining of novel rubiginones from Streptomyces sp. CB02414 and characterization of the post-PKS modification steps in rubiginone biosynthesis
    Zhang, Jingyan
    Sun, Ying
    Wang, Yeji
    Chen, Xin
    Xue, Lu
    Zhang, Jingjing
    Zhu, Xiangcheng
    Duan, Yanwen
    Yan, Xiaohui
    MICROBIAL CELL FACTORIES, 2021, 20 (01)
  • [25] A New Thermolabile Alkaline Phospholipase D from Streptomyces sp CS628
    Simkhada, Jaya Ram
    Cho, Seung Sik
    Choi, Hong Seok
    Kim, Si Wouk
    Lee, Hei Chan
    Sohng, Jae Kyung
    Yoo, Jin Cheol
    BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2010, 15 (04) : 595 - 602
  • [26] New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp CNQ-509
    Park, Jin-Soo
    Kwon, Hak Cheol
    MARINE DRUGS, 2018, 16 (03):
  • [27] Biochemical Characterization of Xylanases from Streptomyces sp. B6 and Their Application in the Xylooligosaccharide Production from Viscose Fiber Production Waste
    Liu, Lin
    Xu, Mingyuan
    Cao, Yanli
    Wang, Hai
    Shao, Jing
    Xu, Meiqing
    Zhang, Yuancheng
    Wang, Yunhe
    Zhang, Weixin
    Meng, Xiangfeng
    Liu, Weifeng
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 68 (10) : 3184 - 3194
  • [28] Akashins A, B, and C:: Novel chlorinated indigoglycosides from Streptomyces sp GW 48/1497
    Maskey, RP
    Grün-Wollny, I
    Fiebig, HH
    Laatsch, H
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2002, 41 (04) : 597 - +
  • [29] Sequence, molecular structure, and catalytic mechanism of four hypothetical tannases from Streptomyces sp. 303MFCol5.2
    Zeng, Huan
    Bai, Danqi
    Zhao, Dongfang
    Hu, Xing
    Zhang, Peng
    Deng, Zeyuan
    FOOD BIOSCIENCE, 2025, 63
  • [30] Isolation and structure determination of a new antibacterial lanthipeptide derived from the marine derived bacterium Lysinibacillus sp.CTST325
    Thetsana, Chanaphat
    Moriuchi, Ryota
    Kodani, Shinya
    WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2025, 41 (02)
12345