Killing kinetics of caspofungin, micafungin, and amphotericin B against Candida guilliermondii

被引：31

作者：

Canton, Emilia

Peman, Javier

Sastre, Macrina

Romero, Monica

Espinel-Ingroff, Ana

机构：

[1] Hosp Univ La Fe, Ctr Invest, Unidad Microbiol Expt, Valencia 46009, Spain

[2] Hosp Univ La Fe, Microbiol Serv, Valencia 46009, Spain

[3] Virginia Commonwealth Univ, Med Ctr, Div Infect Dis, Richmond, VA 23298 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 08期

关键词：

D O I：

10.1128/AAC.00524-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Amphotericin B (AMB), micafungin, and caspofungin MICs, minimal fungicidal concentrations, and time-killing curves were determined in the presence and absence of 10% inactivated serum. AMB was the only agent with consistent killing activity (time required to achieve 99.9% of growth reduction was 2.1 to 3.2 h). The presence of serum enhanced caspofungin activity but lowered those of micafungin and AMB.

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页码：2829 / 2832

页数：4

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