Killing kinetics of caspofungin, micafungin, and amphotericin B against Candida guilliermondii

被引：31
作者：
Canton, Emilia
Peman, Javier
Sastre, Macrina
Romero, Monica
Espinel-Ingroff, Ana
机构：
[1] Hosp Univ La Fe, Ctr Invest, Unidad Microbiol Expt, Valencia 46009, Spain
[2] Hosp Univ La Fe, Microbiol Serv, Valencia 46009, Spain
[3] Virginia Commonwealth Univ, Med Ctr, Div Infect Dis, Richmond, VA 23298 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 08期
关键词：
D O I：
10.1128/AAC.00524-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Amphotericin B (AMB), micafungin, and caspofungin MICs, minimal fungicidal concentrations, and time-killing curves were determined in the presence and absence of 10% inactivated serum. AMB was the only agent with consistent killing activity (time required to achieve 99.9% of growth reduction was 2.1 to 3.2 h). The presence of serum enhanced caspofungin activity but lowered those of micafungin and AMB.
引用
收藏
页码：2829 / 2832
页数：4
相关论文
共 24 条
  • [1] Infectious crystalline keratopathy caused by Candida guilliermondii
    Ainbinder, DJ
    Parmley, VC
    Mader, TH
    Nelson, ML
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 1998, 125 (05) : 723 - 725
  • [2] [Anonymous], 2002, M27A2 CLSI
  • [3] Quality control limits for broth microdilution susceptibility tests of ten antifungal agents
    Barry, AL
    Pfaller, MA
    Brown, SD
    Espinel-Ingroff, A
    Ghannoum, MA
    Knapp, C
    Rennie, RP
    Rex, JH
    Rinaldi, MG
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (09) : 3457 - 3459
  • [4] In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872)
    Bartizal, K
    Gill, CJ
    Abruzzo, GK
    Flattery, AM
    Kong, L
    Scott, PM
    Smith, JG
    Leighton, CE
    Bouffard, A
    Dropinski, JF
    Balkovec, J
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) : 2326 - 2332
  • [5] Patterns of amphotericin B killing kinetics against seven Candida species
    Cantón, E
    Pemán, J
    Gobernado, M
    Viudes, A
    Espinel-Ingroff, A
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (07) : 2477 - 2482
  • [6] Minimum fungicidal concentrations of amphotericin B for bloodstream Candida species
    Cantón, E
    Pemán, J
    Viudes, A
    Quindós, G
    Gobernado, M
    Espinel-Ingroff, A
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2003, 45 (03) : 203 - 206
  • [7] Influence of human sera on the in vitro activity of the echinocandin caspofungin (MK-0991) against Aspergillus fumigatus
    Chiller, T
    Farrokhshad, K
    Brummer, E
    Stevens, DA
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (12) : 3302 - 3305
  • [8] FATAL DISSEMINATED CANDIDIASIS DUE TO AMPHOTERICIN-B-RESISTANT CANDIDA-GUILLIERMONDII
    DICK, JD
    ROSENGARD, BR
    MERZ, WG
    STUART, RK
    HUTCHINS, GM
    SARAL, R
    [J]. ANNALS OF INTERNAL MEDICINE, 1985, 102 (01) : 67 - 68
  • [9] In vitro activity of micafungin (FK-463) against Candida spp.:: Microdilution, time-kill, and postantifungal-effect studies
    Ernst, EJ
    Roling, EE
    Petzold, CR
    Keele, DJ
    Klepser, ME
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (12) : 3846 - 3853
  • [10] Comparison of in vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts
    Espinel-Ingroff, A
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (10) : 2950 - 2956
123