Synthesis of Novel Benzoquinones with Anti-Inflammatory Activity

被引：11

作者：

Sagnou, Marina ^{[1
]}

Strongilos, Alexandros ^{[2
]}

Hadjipavlou-Litina, Dimitra ^{[3
]}

Couladouros, Elias A. ^{[4
]}

机构：

[1] NCSR Demokritos, Inst Biol, Athens 15310, Greece

[2] PRO ACTINA SA, Athens, Greece

[3] Aristotle Univ Thessaloniki, Dept Pharmaceut Chem, Sch Pharm, Thessaloniki 54124, Greece

[4] Agr Univ Athens, Chem Labs, Athens 11855, Greece

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 03期

关键词：

Shikonin; Inflammation; Psoriasis; LOX; Radical scavengers; Benzoquinones; 5-LIPOXYGENASE; SHIKONIN; INHIBITORS; INFLAMMATION; DERIVATIVES; ACTIVATION; ALKANNIN; BRAIN;

D O I：

10.2174/157018009787847792

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some novel benzoquinones and their dimethoxy chemical precursors were synthesized based on shikonin structural features. The quinone functionality showed strong. OH radical scavenging, whereas benzoquinones with an hydroxy-containing saturated side chain exhibited increased soybean lipoxygenase inhibition. Compounds 5, 5b and 7 were superior to indomethacin in vivo in the carrageenin-induced rat paw edema inhibition.

引用

页码：172 / 177

页数：6

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