Clinical Characteristics of Patients with Gastric Perforation following Endoscopic Submucosal Resection for Gastric Cancer

Background/Aims: The aim of this study was to evaluate the risk factors of perforation during endoscopic submucosal dissection (ESD). Methodology: ESD was performed using a Flex knife in 64 patients with a total of 67 gastric tumors. Perforation occurred at the sites of a total of 4 lesions (5.9% [4/67]) for which conservative treatment had been effective. We evaluated several possible risk factors for perforation following ESD, such as tumor size, the location of the lesion, the operation time, and other clinical factors. Results: All the perforations occurred in the posterior wall of the gastric upper or middle body. In an analysis adjusted for age and sex, the tumor size (odds ratio (OR), 1.017; 95% confidence interval (CI), 1.004-1.030), the location of the lesion in an upper region (OR, 10.64; 95%CI, 1.160-10.00) and the operation time (OR, 1.017; 95%CI, 1.013-1.295) were significantly associated with the incidence of perforation. All perforations were transient, resolving within 7 days, and did not require surgical treatment. Conclusions: A large tumor size, the location of the lesion in an upper region, and a long operation time are risk factors for perforation following ESD.