Photoremovable protecting groups: reaction mechanisms and applications

被引：549
作者：
Pelliccioli, AP [1 ]
Wirz, J [1 ]
机构：
[1] Univ Basel, Inst Phys Chem, CH-4056 Basel, Switzerland
来源：
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2002年 / 1卷 / 07期
关键词：
D O I：
10.1039/b200777k
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Photolabile protecting groups enable biochemists to control the release of bioactive compounds in living tissue. 'Caged compounds' (photoactivatable bioagents) have become an important tool to study the events that follow chemical signalling in, e.g., cell biology and the neurosciences. The possibilities are by no means exhausted. Progress will depend on the development of photoremovable protecting groups that satisfy the diverse requirements of new applications-a challenging task for photochemists.
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收藏
页码：441 / 458
页数：18
相关论文
共 177 条
[21]   Calcium sensitivity of glutamate release in a calyx-type terminal [J].
Bollmann, JH ;
Sakmann, B ;
Gerard, J ;
Borst, G .
SCIENCE, 2000, 289 (5481) :953-957
[22]   Synthesis and characterization of photolabile derivatives of serotonin for chemical kinetic investigations of the serotonin 5-HT3 receptor [J].
Breitinger, HGA ;
Wieboldt, R ;
Ramesh, D ;
Carpenter, BK ;
Hess, GP .
BIOCHEMISTRY, 2000, 39 (18) :5500-5508
[23]  
Brown E B, 1998, Methods Enzymol, V291, P356
[24]   Photolysis of caged calcium in femtoliter volumes using two-photon excitation [J].
Brown, EB ;
Shear, JB ;
Adams, SR ;
Tsien, RY ;
Webb, WW .
BIOPHYSICAL JOURNAL, 1999, 76 (01) :489-499
[25]   Synthesis, kinetics, and structural studies of a photolabile caged isocitrate: A catalytic trigger for isocitrate dehydrogenase [J].
Brubaker, MJ ;
Dyer, DH ;
Stoddard, B ;
Koshland, DE .
BIOCHEMISTRY, 1996, 35 (09) :2854-2864
[26]  
Callamaras N, 1998, Methods Enzymol, V291, P380
[27]   Photogeneration of amines from alpha-keto carbamates: Photochemical studies [J].
Cameron, JF ;
Willson, CG ;
Frechet, JMJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (51) :12925-12937
[28]   Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters [J].
Canepari, M ;
Nelson, L ;
Papageorgiou, G ;
Corrie, JET ;
Ogden, D .
JOURNAL OF NEUROSCIENCE METHODS, 2001, 112 (01) :29-42
[29]  
Cepus V, 1998, Methods Enzymol, V291, P223
[30]   Caged catalytic subunit of cAMP-dependent protein kinase [J].
Chang, CY ;
Fernandez, T ;
Panchal, R ;
Bayley, H .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (30) :7661-7662
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