Effect of Poloxamer 407 as a carrier vehicle on rotator cuff healing in a rat model

被引:8
作者
Kim, Soung-Yon [1 ]
Chae, Soo-Won [2 ]
Lee, Juneyoung [3 ]
机构
[1] Hallym Univ, Kangnam Sacred Heart Hosp, Dept Orthopaed Surg, Seoul 150950, South Korea
[2] Korea Univ, Dept Mech Engn, Seoul 136713, South Korea
[3] Korea Univ, Coll Med, Dept Biostat, Seoul 136705, South Korea
来源
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH | 2014年 / 9卷
基金
新加坡国家研究基金会;
关键词
Rotator cuff; Carrier vehicle; Healing; Histological analysis; Biomechanical testing; STRUCTURAL FAILURE; REPAIR; TENDON; SUPRASPINATUS; INTEGRITY; BONE; AUGMENTATION; TEARS;
D O I
10.1186/1749-799X-9-12
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Background: In vivo studies showing the effects of biologic healing-promoting factors on tendon-to-bone healing after rotator cuff repair have focused only on biologic healing-promoting factors and have not taken into consideration the effect of the carrier vehicle. Moreover, most studies have evaluated the healing process using different carrier vehicles, each of which may have specific effects on tendon healing. This may explain the large variability seen in outcomes in research studies. In this study, we investigated the effects of Poloxamer 407 as a carrier vehicle on rotator cuff healing at the repair site and compared it with those of a collagen sponge, which is a commonly used carrier vehicle. Methods: Fifty-seven adult male Sprague-Dawley rats underwent detachment and immediate repair of the bilateral supraspinatus tendons. Rats were randomly assigned to three groups: repair only, repair with collagen sponge, and repair with Poloxamer 407. The repairs were evaluated at 1, 2, 4, and 8 weeks after surgery with histological analysis and biomechanical testing. Results: At 4 weeks, more cellular organization, a greater number of collagen fibers, and increased maturity of collagen fibers were observed in the repair with Poloxamer 407 group than in the other groups. The repair with collagen sponge group had delayed development and collagen fiber maturation. Significant differences in the biomechanical properties were found between groups at 4 weeks. Stiffness in the case of the repair with Poloxamer 407 group was significantly higher than that in the repair with collagen sponge group. The modulus was significantly lower in the repair with collagen sponge group than in the repair only group. However, the use of Poloxamer 407 versus the collagen sponge did not significantly affect the biomechanical properties of the repaired tendons at 8 weeks. Conclusions: Carrier vehicles may have differing effects at the early stages of rotator cuff healing. The use of Poloxamer 407 as a carrier vehicle may be useful for promoting the early stages of healing and for maintaining the initial biomechanical properties of the repaired rotator cuff tendon.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Nonabsorbable Suture Knot on the Tendon Affects Rotator Cuff Healing: A Comparative Study of the Knots on Tendon and Bone in a Rat Model of Rotator Cuff Tear
    Sun, Yucheng
    Kwak, Jae-Man
    Kholinne, Erica
    Tan, Jun
    Koh, Kyoung-Hwan
    Jeon, In-Ho
    AMERICAN JOURNAL OF SPORTS MEDICINE, 2019, 47 (12) : 2809 - 2815
  • [42] Does Demineralized Bone Matrix Enhance Tendon-to-Bone Healing after Rotator Cuff Repair in a Rabbit Model?
    Lee, Woo-Yong
    Kim, Young-Mo
    Hwang, Deuk-Soo
    Shin, Hyun-Dae
    Joo, Yong-Bum
    Cha, Soo Min
    Kim, Kyung-Hee
    Jeon, Yoo-Sun
    Lee, Sun-Yeul
    CLINICS IN ORTHOPEDIC SURGERY, 2021, 13 (02) : 216 - 222
  • [43] Effectiveness of Bone Marrow-Derived Platelet-Rich Fibrin on Rotator Cuff Healing in a Rabbit Degenerative Model
    Uno, Tomohiro
    Maruyama, Masahiro
    Satake, Hiroshi
    Takakubo, Yuya
    Toyono, Shuji
    Xing, Liu
    Huang, Hanqing
    Yuki, Issei
    Suzuki, Akemi
    Mura, Nariyuki
    Takagi, Michiaki
    AMERICAN JOURNAL OF SPORTS MEDICINE, 2022, 50 (12) : 3341 - 3354
  • [44] A Combination Treatment of Raloxifene and Vitamin D Enhances Bone-to-Tendon Healing of the Rotator Cuff in a Rat Model
    Kim, Dong Min
    Shim, In Kyoung
    Shin, Myung Jin
    Choi, Jae Hee
    Lee, Yu Na
    Jeon, In-Ho
    Kim, Hyojune
    Park, Dongjun
    Kholinne, Erica
    Koh, Kyoung-Hwan
    AMERICAN JOURNAL OF SPORTS MEDICINE, 2020, 48 (09) : 2161 - 2169
  • [45] Poly-N-Acetyl Glucosamine (sNAG) Enhances Early Rotator Cuff Tendon Healing in a Rat Model
    Nuss, C. A.
    Huegel, J.
    Boorman-Padgett, J. F.
    Choi, D. S.
    Weiss, S. N.
    Vournakis, J.
    Soslowsky, L. J.
    ANNALS OF BIOMEDICAL ENGINEERING, 2017, 45 (12) : 2826 - 2836
  • [46] Is a Local Administration of Parathyroid Hormone Effective to Tendon-to-Bone Healing in a Rat Rotator Cuff Repair Model?
    Yoon, Jong Pil
    Chung, Seok Won
    Jung, Jae Wook
    Lee, Yong-Soo
    Kim, Kwang-Il
    Park, Ga Young
    Kim, Hun-Min
    Choi, Jin-Hyun
    JOURNAL OF ORTHOPAEDIC RESEARCH, 2020, 38 (01) : 82 - 91
  • [47] Comparison of the Characteristics of Rotator Cuff Tissue in a Diabetic Rat Model
    Kim, Dong Hyun
    Min, Seung Gi
    Kim, Hun-Min
    Kang, Hae Rim
    Choi, Jin-Hyun
    Lee, Hyum Joo
    Kim, Kyung-Rock
    Chung, Seok Won
    Yoon, Jong Pil
    ORTHOPEDICS, 2022, 45 (03) : E154 - E161
  • [48] A Rat Model of Massive Rotator Cuff Tears
    Liu, Xuhui
    Manzano, Givenchy
    Kim, Hubert T.
    Feeley, Brian T.
    JOURNAL OF ORTHOPAEDIC RESEARCH, 2011, 29 (04) : 588 - 595
  • [49] Effect of Mechanical Stimulation Combined With Platelet-Rich Plasma on Healing of the Rotator Cuff in a Murine Model
    Peng, Yundong
    Li, Xiaomei
    Wu, Wenxia
    Ma, Haozhe
    Wang, Guanglan
    Jia, Shaohui
    Zheng, Cheng
    AMERICAN JOURNAL OF SPORTS MEDICINE, 2022, 50 (05) : 1358 - 1368
  • [50] Rotator Cuff Tendon Healing Using Human Dermal Fibroblasts: Histological and Biomechanical Analyses in a Rabbit Model of Chronic Rotator Cuff Tears
    Lee, Ji-Hye
    Kim, Yun Hee
    Rhee, Sung-Min
    Han, Jikhyon
    Jeong, Hyeon Jang
    Park, Joo Hyun
    Oh, Joo Han
    Jeon, Saewha
    AMERICAN JOURNAL OF SPORTS MEDICINE, 2021, 49 (13) : 3669 - 3679