Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line

被引：13

作者：

Angel Garcia-Perez, Miguel ^{[2
]}

Pineda, Begona ^{[2
]}

Hermenegildo, Carlos ^{[2
,3
]}

Tarin, Juan J. ^{[4
]}

Cano, Antonio ^{[1
]}

机构：

[1] Univ Valencia, Fac Med, Dept Pediat Obstet & Gynecol, Valencia 46010, Spain

[2] Univ Valencia, Hosp Clin Univ, Res Fdn, Valencia 46010, Spain

[3] Univ Valencia, Dept Physiol, Valencia 46010, Spain

[4] Univ Valencia, Dept Funct Biol & Phys Anthropol, Valencia 46010, Spain

来源：

FERTILITY AND STERILITY | 2009年 / 91卷 / 04期

关键词：

HORMONE REPLACEMENT THERAPY; BLACK COHOSH; POSTMENOPAUSAL WOMEN; ENDOTHELIAL-CELLS; PROSTACYCLIN; RALOXIFENE; TURNOVER; EXTRACT;

D O I：

10.1016/j.fertnstert.2008.03.042

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Postmenopausal women treated with an isopropanolic extract of Cimicifuga racemosa underwent a decrease in the urinary concentration of N-telopeptides, a marker of bone resorption, and an increase in alkaline phosphatase, a marker of bone formation, at the third month of therapy. Serum from treated women did not modify the activity of alkaline phosphatase or the expression of three genes, runt-related transcription factor-2 (Runx-2), alkaline phosphatase, and osteocalcin, when added to the MC3T3-E1 osteoblastic cell line. (Fertil Steril (R) 2009; 91:1347-50. (C)2009 by American Society for Reproductive Medicine.)

引用

页码：1347 / 1350

页数：4

共 14 条

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