Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line

被引：14
作者：
Angel Garcia-Perez, Miguel [2 ]
Pineda, Begona [2 ]
Hermenegildo, Carlos [2 ,3 ]
Tarin, Juan J. [4 ]
Cano, Antonio [1 ]
机构：
[1] Univ Valencia, Fac Med, Dept Pediat Obstet & Gynecol, Valencia 46010, Spain
[2] Univ Valencia, Hosp Clin Univ, Res Fdn, Valencia 46010, Spain
[3] Univ Valencia, Dept Physiol, Valencia 46010, Spain
[4] Univ Valencia, Dept Funct Biol & Phys Anthropol, Valencia 46010, Spain
来源：
FERTILITY AND STERILITY | 2009年 / 91卷 / 04期
关键词：
HORMONE REPLACEMENT THERAPY; BLACK COHOSH; POSTMENOPAUSAL WOMEN; ENDOTHELIAL-CELLS; PROSTACYCLIN; RALOXIFENE; TURNOVER; EXTRACT;
D O I：
10.1016/j.fertnstert.2008.03.042
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Postmenopausal women treated with an isopropanolic extract of Cimicifuga racemosa underwent a decrease in the urinary concentration of N-telopeptides, a marker of bone resorption, and an increase in alkaline phosphatase, a marker of bone formation, at the third month of therapy. Serum from treated women did not modify the activity of alkaline phosphatase or the expression of three genes, runt-related transcription factor-2 (Runx-2), alkaline phosphatase, and osteocalcin, when added to the MC3T3-E1 osteoblastic cell line. (Fertil Steril (R) 2009; 91:1347-50. (C)2009 by American Society for Reproductive Medicine.)
引用
收藏
页码：1347 / 1350
页数：4
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