Design, synthesis, characterization and in vitro antimicrobial evaluation of 4,6-diaryl-4,5-dihydro-2-phenyl-2H-indazol-3-ols

被引：0
|
作者：
Gopalakrishnan, M. [1 ]
Thanusu, J. [1 ]
Kanagarajan, V. [1 ]
机构：
[1] Annamalai Univ, Dept Chem, Synthet Organ Chem Lab, Annamalainagar 608002, Tamil Nadu, India
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2009年 / 24卷 / 02期
关键词：
6-Carbethoxy-3; 5-diarylcyclohex-2-enone; 4; 6-Diaryl-4; 5-dihydro-2-phenyl-2H-indazol-3-ols; Phenyl hydrazine hydrochloride; Antibacterial activity; Antifungal activity; BIOLOGICAL EVALUATION; ALDOL CONDENSATION;
D O I：
10.1080/14756360802218078
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New 4,6-diaryl-4,5-dihydro-2-phenyl-2H-indazol-3-ols 25-32 were designed, synthesized and in vitro microbially evaluated using clinically isolated bacterial strains viz Staphylococcus aureus, -Heamolytic streptococcus, Vibreo cholerae, Salmonella typhii, Shigella felxneri and fungal strains viz Aspergillus flavus, Mucor, Rhizopus and Microsporum gypsuem. Results of this study showed that the nature of the substituents on the phenyl rings viz., methyl, methoxy, chloro, nitro as well as the bromo functions at the meta and para positions of the aryl moieties determined the nature and extent of the activity of the fused indazolonol compounds 25-32. [image omitted].
引用
收藏
页码：480 / 486
页数：7
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