Color Representation Is Retinotopically Biased but Locally Intermingled in Mouse V1

被引:9
作者
Aihara, Shuhei [1 ,4 ]
Yoshida, Takashi [1 ,2 ,3 ]
Hashimoto, Takayuki [1 ]
Ohki, Kenichi [1 ,2 ,3 ]
机构
[1] Kyushu Univ, Grad Sch Med Sci, Dept Mol Physiol, Fukuoka, Japan
[2] Univ Tokyo, Sch Med, Dept Physiol, Tokyo, Japan
[3] Japan Sci & Technol Agcy, Core Res Evolutionary Sci & Technol, Tokyo, Japan
[4] RIKEN, Ctr Dev Biol, Lab Sensory Circuit Format, Kobe, Hyogo, Japan
基金
日本学术振兴会;
关键词
color; mouse; visual cortex; functional architecture; two-photon imaging; wide field Ca2+ imaging; SPECTRAL SENSITIVITY; RESPONSE PROPERTIES; VISUAL-CORTEX; CONE INPUTS; S-CONE; ORGANIZATION; VISION; MICE; COEXPRESSION; MECHANISMS;
D O I
10.3389/fncir.2017.00022
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dichromatic vision is common in many mammals. However, color processing in the primary visual cortex (V1) of dichromatic mammals is relatively unknown compared to the trichromatic primates. In this study, we investigated the functional organization of color processing in mouse V1. The mouse retina has a graded expression pattern of two opsins along its dorsoventral axis. However, it is not clear whether and how this expression pattern is reflected in the cortical representation at local (several hundred microns) and areal (V1) level. Using in vivo two-photon calcium (Ca2+) imaging and wide-field Ca2+ imaging, we revealed that V1 neurons responded to S (UV)- and M (green)-opsin isolating stimuli with slightly biased color preference depending on retinotopic position in V1. This was consistent with the distribution of retinal opsins. At the cellular level, preferences for S- and M-opsin isolating stimuli were intermingled in a local region encompassing several hundred microns. These results suggest that functional organizations of color information are locally intermingled, but slightly biased depending on the retinotopic position in mouse V1.
引用
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页数:12
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