Asymmetric synthesis of syn hydroxyphenylalanine via aziridine ring expansion to an oxazoline

被引：22

作者：

Cardillo, G

Gentilucci, L

Tolomelli, A

机构：

[1] Univ Bologna, CNR, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

[2] Univ Bologna, CNR, CSFM, I-40126 Bologna, Italy

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 47期

关键词：

conjugate additions; hydroxylamines; amino acids; amino acid derivatives; aziridine; oxazolines;

D O I：

10.1016/S0040-4039(99)01734-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of (2R,3S)- and (2S,3R)-hydroxyphenylalanine is reported. The main steps are the 1,4-addition of O-benzylhydroxylamine to unsaturated imides and the ring expansion of trans-aziridines. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：8261 / 8264

页数：4

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