The Effect of Sufentanil Administration on Remifentanil-Based Anaesthesia during Laparoscopic Gynaecological Surgery: A Double-Blind Randomized Controlled Trial

被引:2
作者
Son, Ilsoon [1 ]
Oh, Chung-Sik [1 ]
Choi, Jae Won [1 ]
Kim, Seong-Hyop [1 ,2 ]
机构
[1] Konkuk Univ, Sch Med, Med Ctr, Dept Anaesthesiol & Pain Med, Seoul 143729, South Korea
[2] Konkuk Univ, Sch Med, Inst Biomed Sci & Technol, Seoul 143701, South Korea
来源
SCIENTIFIC WORLD JOURNAL | 2014年
关键词
MAJOR ABDOMINAL-SURGERY; INTRACRANIAL SURGERY; CONTROLLED INFUSION; POSTOPERATIVE PAIN; PHARMACOKINETICS; PROPOFOL; PHARMACODYNAMICS; ANALGESIA; HYPERALGESIA; REQUIREMENT;
D O I
10.1155/2014/701329
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study assessed the effect of sufentanil administered before conclusion of remifentanil-based anaesthesia on postoperative hyperalgesia and haemodynamic stability in patients undergoing laparoscopic gynaecological surgery. The patients were randomly allocated to a sufentanil administration group (S group) or a normal saline administration group (C group). Anaesthesia was induced and maintained with controlled administration of remifentanil at 10 ng.mL(-1) and propofol under bispectral index guidance. Once the surgical specimen was procured, sufentanil or normal saline was administered at 0.15 ng.mL(-1) and maintained until extubation. The haemodynamic status during anaesthetic emergence was evaluated. The pain and postoperative nausea and vomiting (PONV) were assessed for 72 h following postanaesthetic care unit (PACU) discharge. The S group had significantly lower mean systemic arterial blood pressure and heart rate changes between the start of drug administration and extubation. Postoperative pain was significantly lower in the S group until 24 h following PACU discharge. There were no significant differences in PONV incidence and severity 72 h after PACU discharge between the two groups. Sufentanil administration before concluding remifentanil-based anaesthesia improved postoperative hyperalgesia and achieved haemodynamic stability at extubation without delaying recovery or increasing PONV during laparoscopic gynaecological surgery. Clinical trial registration is found at KCT0000785.
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页数:7
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