Iron-mediated remote C-H bond benzylation of 8-aminoquinoline amides

被引：20

作者：

Cui, Mian ^{[1
]}

Liu, Jing-Hui ^{[1
]}

Lu, Xiao-Yu ^{[1
]}

Lu, Xi ^{[1
]}

Zhang, Zhen-Qi ^{[1
]}

Xiao, Bin ^{[1
]}

Fu, Yao ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 20期

关键词：

Two component reaction; C-H functionalization; Iron-catalyzed; Benzylation; Quinoline; FRIEDEL-CRAFTS REACTIONS; DIRECT ARYLATION; CARBON-NITROGEN; UNACTIVATED C(SP(3))-H; CATALYZED CLEAVAGE; COPPER; QUINOLINES; SULFONAMIDES; FUNCTIONALIZATION; ALKYLATION;

D O I：

10.1016/j.tetlet.2017.02.090

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient method for C5-benzylation of quinoline frameworks is developed with the using of inexpensive FeCl3 catalyst. A range of N-bisbenzylic and N-monobenzylic sulfonamides smoothly react with aliphatic amides and aromatic amides, giving the corresponding products in moderate to excellent yields. (C) 2017 Published by Elsevier Ltd.

引用

页码：1912 / 1916

页数：5

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