Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders

被引：53
|
作者：
Richt, JA
Alexander, RC
Herzog, S
Hooper, DC
Kean, R
Spitsin, S
Bechter, K
Schuttler, R
Feldmann, H
Heiske, A
Fu, ZF
Dietzschold, B
Rott, R
Koprowski, H
机构：
[1] THOMAS JEFFERSON UNIV,CTR NEUROVIROL,PHILADELPHIA,PA 19107
[2] THOMAS JEFFERSON UNIV,BIOTECHNOL FDN LABS,DEPT IMMUNOL & MICROBIOL,PHILADELPHIA,PA 19107
[3] UNIV GIESSEN,INST VIROL,D-6300 GIESSEN,GERMANY
[4] UNIV PENN,DEPT PSYCHIAT,CTR STUDIES ADDICT,PHILADELPHIA,PA 19104
[5] BEZIRKSKRANKENHAUS GUNZBURG,GUNZBURG,GERMANY
[6] UNIV ULM,BEZIRKSKRANKENHAUS,DEPT PSYCHIAT 2,GUNZBURG,GERMANY
[7] UNIV MARBURG,INST VIROL,D-3550 MARBURG,GERMANY
来源：
JOURNAL OF NEUROVIROLOGY | 1997年 / 3卷 / 02期
关键词：
Borna disease virus; psychiatric disease; PBLs; RT-PCR;
D O I：
10.3109/13550289709015807
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.
引用
收藏
页码：174 / 178
页数：5
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