Cerebrospinal Fluid α-Synuclein Species in Cognitive and Movements Disorders

被引：27
作者：
Constantinides, Vasilios C. [1 ,2 ]
Majbour, Nour K. [3 ]
Paraskevas, George P. [1 ]
Abdi, Ilham [3 ]
Safieh-Garabedian, Bared [4 ]
Stefanis, Leonidas [2 ]
El-Agnaf, Omar M. [3 ]
Kapaki, Elisabeth [1 ,2 ]
机构：
[1] Natl & Kapodistrian Univ Athens, Dept Neurol 1, Neurochem & Biomarkers Unit, Athens 11528, Greece
[2] Natl & Kapodistrian Univ Athens, Dept Neurol 1, Ward Cognit & Movement Disorders, Athens 11528, Greece
[3] Hamad Bin Khalifa Univ HBKU, Qatar Fdn, Qatar Biomed Res Inst QBRI, Neurol Disorders Res Ctr, Doha 34110, Qatar
[4] Qatar Univ, Coll Med, QU Hlth, Doha 2713, Qatar
来源：
BRAIN SCIENCES | 2021年 / 11卷 / 01期
关键词：
α -synuclein; cerebrospinal fluid; biomarkers; tau proteins; beta amyloid; parkinsonism; dementia; neurodegenerative disorders;
D O I：
10.3390/brainsci11010119
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Total CSF alpha-synuclein (t-alpha-syn), phosphorylated alpha-syn (pS129-alpha-syn) and alpha-syn oligomers (o-alpha-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the differentiation from healthy controls. Studies of alpha-syn species in patients with other underlying pathologies are lacking. The aim of this study was to investigate possible alterations in CSF alpha-syn species in a cohort of patients with diverse underlying pathologies. A total of 135 patients were included, comprising Parkinson's disease (PD; n = 13), multiple system atrophy (MSA; n = 9), progressive supranuclear palsy (PSP; n = 13), corticobasal degeneration (CBD; n = 9), Alzheimer's disease (AD; n = 51), frontotemporal degeneration (FTD; n = 26) and vascular dementia patients (VD; n = 14). PD patients exhibited higher pS129-alpha-syn/alpha-syn ratios compared to FTD (p = 0.045), after exclusion of samples with CSF blood contamination. When comparing movement disorders (i.e., MSA vs. PD vs. PSP vs. CBD), MSA patients had lower alpha-syn levels compared to CBD (p = 0.024). Patients with a synucleinopathy (PD and MSA) exhibited lower t-alpha-syn levels (p = 0.002; cut-off value: <= 865 pg/mL; sensitivity: 95%, specificity: 69%) and higher pS129-/t-alpha-syn ratios (p = 0.020; cut-off value: >= 0.122; sensitivity: 71%, specificity: 77%) compared to patients with tauopathies (PSP and CBD). There are no significant alpha-syn species alterations in non-synucleinopathies.
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页码：1 / 12
页数：12
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