Association between Cancer and Alzheimer's Disease: Systematic Review and Meta-Analysis

被引：57
作者：
Ma, Ling-Li [1 ]
Yu, Jin-Tai [2 ,3 ]
Wang, Hui-Fu [3 ]
Meng, Xiang-Fei [2 ]
Tan, Chen-Chen [2 ]
Wang, Chong [2 ]
Tan, Lan [1 ,2 ,3 ]
机构：
[1] Weifang Med Univ, Qingdao Municipal Hosp, Dept Neurol, Shandong, Peoples R China
[2] Qingdao Univ, Qingdao Municipal Hosp, Sch Med, Dept Neurol, Qingdao 266071, Peoples R China
[3] Nanjing Med Univ, Qingdao Municipal Hosp, Dept Neurol, Shandong, Peoples R China
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2014年 / 42卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; cancer; meta-analysis; neoplasm; BREAST-CANCER; CELL-DEATH; CIGARETTE-SMOKING; C-JUN; POPULATION; PIN1; DIAGNOSIS; RISK;
D O I：
10.3233/JAD-140168
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study examined the association between cancer and Alzheimer's disease (AD) by a quantitative meta-analysis of cohort studies. Studies were identified by searching PubMed database through 1966 to December 2013 using the terms "Alzheimer's disease", "neoplasm", and "cancer". Six studies met the inclusion criteria in the overall meta-analysis. We pooled effect sizes using fixed-effects and random-effects models. Furthermore, we also tested for heterogeneity and publication bias. The results suggested that individuals diagnosed with AD had a decreased risk for incident cancer by 42% (95% CI, 0.40-0.86; p < 0.05), and patients with a history of cancer had a 37% decreased risk of AD (RR = 0.63; 95% CI, 0.56-0.72; p = 0.495). The Egger's test for publication bias (p = 0.280) showed no significant evidence for bias in the data from studies on AD and cancer risk. In summary, our meta-analysis demonstrated an inverse association between cancer and AD.
引用
收藏
页码：565 / 573
页数：9
相关论文
共 32 条
  • [1] Prevalent overexpression of prolyl isomerase Pin1 in human cancers
    Bao, L
    Kimzey, A
    Sauter, G
    Sowadski, JM
    Lu, KP
    Wang, DG
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2004, 164 (05) : 1727 - 1737
  • [2] Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity
    Barone, Maria Cecilia
    Desouza, Lynette A.
    Freeman, Robert S.
    [J]. JOURNAL OF NEUROCHEMISTRY, 2008, 106 (02) : 734 - 745
  • [3] Pin1 in neuronal apoptosis
    Becker, Esther B. E.
    Bonni, Azad
    [J]. CELL CYCLE, 2007, 6 (11) : 1332 - 1335
  • [4] RELATIONSHIP BETWEEN CIGARETTE-SMOKING AND ALZHEIMERS-DISEASE IN A POPULATION-BASED CASE-CONTROL STUDY
    BRENNER, DE
    KUKULL, WA
    VANBELLE, G
    BOWEN, JD
    MCCORMICK, WC
    TERI, L
    LARSON, EB
    [J]. NEUROLOGY, 1993, 43 (02) : 293 - 300
  • [5] A prospective cohort study of cancer incidence following the diagnosis of Parkinson's disease
    Driver, Jane A.
    Logroscino, Giancarlo
    Buring, Julie E.
    Gaziano, J. Michael
    Kurth, Tobias
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (06) : 1260 - 1265
  • [6] Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study
    Driver, Jane A.
    Beiser, Alexa
    Au, Rhoda
    Kreger, Bernard E.
    Splansky, Greta Lee
    Kurth, Tobias
    Kiel, Douglas P.
    Lu, Kun Ping
    Seshadri, Sudha
    Wolf, Phillip A.
    [J]. BRITISH MEDICAL JOURNAL, 2012, 344 : 19
  • [7] Relationship Between Chemotherapy Use and Cognitive Impairments in Older Women With Breast Cancer Findings From a Large Population-Based Cohort
    Du, Xianglin L.
    Xia, Rui
    Hardy, Dale
    [J]. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2010, 33 (06): : 533 - 543
  • [8] PROSPECTIVE-STUDY OF CIGARETTE-SMOKING AND THE RISK OF DEVELOPING IDIOPATHIC PARKINSONS-DISEASE
    GRANDINETTI, A
    MORENS, DM
    REED, D
    MACEACHERN, D
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1994, 139 (12) : 1129 - 1138
  • [9] No Association Between Hypertension and Risk for Alzheimer's Disease: A Meta-Analysis of Longitudinal Studies
    Guan, Jun-Wen
    Huang, Chang-Quan
    Li, Yong-Hong
    Wan, Chao-Min
    You, Chao
    Wang, Zheng-Rong
    Liu, Yan-You
    Liu, Qing-Xiu
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2011, 27 (04) : 799 - 807
  • [10] Alzheimer disease in the US population - Prevalence estimates using the 2000 census
    Hebert, LE
    Scherr, PA
    Bienias, JL
    Bennett, DA
    Evans, DA
    [J]. ARCHIVES OF NEUROLOGY, 2003, 60 (08) : 1119 - 1122
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