Pharmacodynamics of T cell function for monitoring pharmacologic immunosuppression after allogeneic hematopoietic stem cell transplantation

被引：3
作者：
Martinez, Carmen [1 ,2 ,5 ,6 ]
Millan, Olga [3 ,4 ,5 ,6 ]
Rovira, Montserrat [1 ,2 ,5 ,6 ]
Fernandez-Aviles, Francesc [1 ,2 ,5 ,6 ]
Lopez, Anna [3 ,5 ]
Suarez-Lledo, Maria [1 ]
Carreras, Enric [2 ]
Urbano-Ispizua, Alvaro [2 ,5 ,6 ]
Brunet, Merce [3 ,4 ,5 ,6 ]
机构：
[1] Univ Barcelona, Inst Hematol & Oncol, Hosp Clin, Dept Hematol, Villarroel 170, Barcelona 08039, Spain
[2] Univ Barcelona, Inst Josep Carreras, Hosp Clin, Barcelona, Spain
[3] Univ Barcelona, Hosp Clin, Pharmacol & Toxicol Dept, Biomed Diagnost Ctr, Barcelona, Spain
[4] Univ Barcelona, Hosp Clin, CIBERehd, Barcelona, Spain
[5] Univ Barcelona, Inst Invest Biomed Agusti Pi & Sunyer IDIBAPS, Hosp Clin, Barcelona, Spain
[6] Univ Barcelona, Hosp Clin, Barcelona, Spain
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2017年 / 105卷 / 04期
关键词：
Graft-versus-host disease; Treg cells; T effector cells; Pharmacodynamics; Allogeneic stem cell transplantation; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; MYCOPHENOLATE-MOFETIL; ACUTE REJECTION; IMMUNE FUNCTION; IFN-GAMMA; RECIPIENTS; PHARMACOKINETICS; CYCLOSPORINE; TACROLIMUS;
D O I：
10.1007/s12185-016-2145-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Information on pharmacodynamic monitoring after allogeneic hematopoietic cell transplantation (allo-SCT) to evaluate individual responses to immunosuppressive drugs is scarce. We studied the relationship between a panel of pharmacodynamic markers monitored during the first 3 months after transplant and the occurrence of graft-versus-host disease (GVHD). Lymphocyte activation assessed by intracellular ATP concentration in CD4(+) T cells, a high percentage of CD8(+) effector T cells, and a low percentage of CD4(+) regulatory T (Treg) cells correlated significantly with GVHD. A cutoff value of 0.5 for the CD8(+) effector T/Treg ratio provided the most accurate diagnosis of GVHD (sensitivity 58.8%, specificity 91%). These pharmacodynamic markers may provide an efficient complement to standard pharmacokinetic monitoring of immunosuppressive drugs after allo-SCT.
引用
收藏
页码：497 / 505
页数：9
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