Pharmacodynamics of T cell function for monitoring pharmacologic immunosuppression after allogeneic hematopoietic stem cell transplantation

被引：3

作者：

Martinez, Carmen ^{[1
,2
,5
,6
]}

Millan, Olga ^{[3
,4
,5
,6
]}

Rovira, Montserrat ^{[1
,2
,5
,6
]}

Fernandez-Aviles, Francesc ^{[1
,2
,5
,6
]}

Lopez, Anna ^{[3
,5
]}

Suarez-Lledo, Maria ^{[1
]}

Carreras, Enric ^{[2
]}

Urbano-Ispizua, Alvaro ^{[2
,5
,6
]}

Brunet, Merce ^{[3
,4
,5
,6
]}

机构：

[1] Univ Barcelona, Inst Hematol & Oncol, Hosp Clin, Dept Hematol, Villarroel 170, Barcelona 08039, Spain

[2] Univ Barcelona, Inst Josep Carreras, Hosp Clin, Barcelona, Spain

[3] Univ Barcelona, Hosp Clin, Pharmacol & Toxicol Dept, Biomed Diagnost Ctr, Barcelona, Spain

[4] Univ Barcelona, Hosp Clin, CIBERehd, Barcelona, Spain

[5] Univ Barcelona, Inst Invest Biomed Agusti Pi & Sunyer IDIBAPS, Hosp Clin, Barcelona, Spain

[6] Univ Barcelona, Hosp Clin, Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2017年 / 105卷 / 04期

关键词：

Graft-versus-host disease; Treg cells; T effector cells; Pharmacodynamics; Allogeneic stem cell transplantation; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; MYCOPHENOLATE-MOFETIL; ACUTE REJECTION; IMMUNE FUNCTION; IFN-GAMMA; RECIPIENTS; PHARMACOKINETICS; CYCLOSPORINE; TACROLIMUS;

D O I：

10.1007/s12185-016-2145-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Information on pharmacodynamic monitoring after allogeneic hematopoietic cell transplantation (allo-SCT) to evaluate individual responses to immunosuppressive drugs is scarce. We studied the relationship between a panel of pharmacodynamic markers monitored during the first 3 months after transplant and the occurrence of graft-versus-host disease (GVHD). Lymphocyte activation assessed by intracellular ATP concentration in CD4(+) T cells, a high percentage of CD8(+) effector T cells, and a low percentage of CD4(+) regulatory T (Treg) cells correlated significantly with GVHD. A cutoff value of 0.5 for the CD8(+) effector T/Treg ratio provided the most accurate diagnosis of GVHD (sensitivity 58.8%, specificity 91%). These pharmacodynamic markers may provide an efficient complement to standard pharmacokinetic monitoring of immunosuppressive drugs after allo-SCT.

引用

页码：497 / 505

页数：9

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