Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives

被引：35

作者：

da Rosa, Raquel Mello ^{[1
]}

Piccoli, Bruna Candia ^{[2
]}

da Silva, Fernanda D'Avila ^{[2
]}

Dornelles, Luciano ^{[1
]}

Rocha, Joao B. T. ^{[2
]}

Sonego, Mariana Souza ^{[3
]}

Begnini, Karine Rech ^{[3
]}

Collares, Tiago ^{[3
]}

Seixasc, Fabiana K. ^{[3
]}

Rodrigues, Oscar E. D. ^{[1
]}

机构：

[1] Univ Fed Santa Maria, LabSelen NanoBio Dept Quim, Santa Maria, RS, Brazil

[2] Univ Fed Santa Maria, Programa PosGrad Ciecias Biolog, Bioquim Toxicol, Santa Maria, RS, Brazil

[3] Univ Fed Pelotas, Mol & Cellular Oncol Grp, Grad Program Biotechnol, Pelotas, Brazil

来源：

MEDCHEMCOMM | 2017年 / 8卷 / 02期

关键词：

TELLURIUM COMPOUNDS; GENE-EXPRESSION; ANTI-HIV; ANALOGS; NUCLEOSIDE; CANCER; ORGANOSELENIUM; MECHANISMS; RESISTANCE; DESIGN;

D O I：

10.1039/c6md00640j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article presents the preparation and in vitro biological activities of new 5'-arylchalcogeno-3aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.

引用

页码：408 / 414

页数：7

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