Ideal enantiomeric resolution by recrystallization of a racemic compound

被引：0
作者：
Tamura, R
Ushio, T
Nakamura, K
Takahashi, H
Azuma, N
Toda, F
机构：
[1] TAIHO PHARMACEUT CO LTD,KAMIKAWA,SAITAMA 36702,JAPAN
[2] EHIME UNIV,FAC ENGN,DEPT APPL CHEM,MATSUYAMA,EHIME 79077,JAPAN
[3] EHIME UNIV,FAC SCI,DEPT CHEM,MATSUYAMA,EHIME 79077,JAPAN
来源：
ENANTIOMER | 1997年 / 2卷 / 3-4期
关键词：
enantiomeric resolution; recrystallization; racemic compound crystal; enantiomeric enrichment in solution; X-ray crystal structure; reversal of chirality;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An unusual but ideal enantiomeric resolution phenomenon observed upon recrystallization of a racemate is described. The X-ray crystallographic analysis of the racemate showed that it is a racemic compound composed of a regular packing of a pair of (+) and (-) molecules.
引用
收藏
页码：277 / 280
页数：4
相关论文
共 5 条
[1]   OPTICAL RESOLUTION BY DIRECT CRYSTALLIZATION OF ENANTIOMER MIXTURES [J].
COLLET, A ;
BRIENNE, MJ ;
JACQUES, J .
CHEMICAL REVIEWS, 1980, 80 (03) :215-230
[2]  
Jacques J., 1981, ENANTIOMERS RACEMATE, P217
[3]   Polymorphism of compound existing as both racemic compound crystals and mixed crystals of enantiomers [J].
Ushio, T ;
Tamura, R ;
Azuma, N ;
Nakamura, K ;
Toda, F ;
Kobayashi, K .
MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 1996, 276 :245-252
[4]   HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF ENANTIOMERS OF (2-[4-(3-ETHOXY-2-HYDROXYPROPOXY)PHENYLCARBAMOYL]ETHYL)-DIMETHYLSULFONIUM P-TOLUENESULFONATE (SUPLATAST TOSILATE) ON A CELLULOSE TRIS-3,5-DIMETHYLPHENYLCARBAMATE COLUMN [J].
USHIO, T ;
YAMAMOTO, K .
JOURNAL OF CHROMATOGRAPHY A, 1994, 684 (02) :235-242
[5]   Unusual enantiomeric resolution phenomenon observed upon recrystallization of a racemic compound [J].
Ushio, T ;
Tamura, R ;
Takahashi, H ;
Azuma, N ;
Yamamoto, K .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (20) :2372-2374
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