Molecular Pathogenesis of Cholangiocarcinoma

被引：24

作者：

Rizvi, Sumera ^{[1
]}

Gores, Gregory J. ^{[1
]}

机构：

[1] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

来源：

DIGESTIVE DISEASES | 2014年 / 32卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Cancer-associated fibroblast; Cholangiocarcinoma; Inflammation; Tumor microenvironment; INDUCE CYCLOOXYGENASE-2 EXPRESSION; ISOCITRATE DEHYDROGENASE 1; GROWTH-FACTOR RECEPTOR; INTRAHEPATIC CHOLANGIOCARCINOMA; DNA-DAMAGE; CANCER; CELLS; OXYSTEROLS; BILE; CHOLANGIOCYTES;

D O I：

10.1159/000360502

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

It has become increasingly apparent of late that inflammation plays an integral role in a spectrum of malignancies including cholangiocarcinoma (CCA). Primary sclerosing cholangitis with chronic inflammation is the most common risk factor for CCA in the Western world. Recent work has highlighted that inflammatory pathways are essential in carcinogenesis and tissue invasion and migration. Inflammation advances carcinogenesis by induction of DNA damage, evasion of apoptosis, promotion of cell proliferation, and neoangiogenesis. CCA is characterized by the presence of a desmoplastic stroma consisting of cancer-associated fibroblasts, tumor-associated macrophages, and tumor-infiltrating lymphocytes. This rich inflammatory milieu is vital to the cancer ecosystem, and targeting its components represents an attractive therapeutic option. (C) 2014 S. Karger AG, Basel

引用

页码：564 / 569

页数：6

共 45 条

[1] Chromosome 9p21 loss and p16 inactivation in primary sclerosing cholangitis-associated cholangiocarcinoma [J].

Ahrendt, SA ;

Eisenberger, CF ;

Yip, L ;

Rashid, A ;

Chow, JT ;

Pitt, HA ;

Sidransky, D .

JOURNAL OF SURGICAL RESEARCH, 1999, 84 (01) :88-93

[2] Genetic profiling of intrahepatic cholangiocarcinoma [J].

Andersen, Jesper B. ;

Thorgeirsson, Snorri S. .

CURRENT OPINION IN GASTROENTEROLOGY, 2012, 28 (03) :266-272

[3] Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors [J].

Andersen, Jesper B. ;

Spee, Bart ;

Blechacz, Boris R. ;

Avital, Itzhak ;

Komuta, Mina ;

Barbour, Andrew ;

Conner, Elizabeth A. ;

Gillen, Matthew C. ;

Roskams, Tania ;

Roberts, Lewis R. ;

Factor, Valentina M. ;

Thorgeirsson, Snorri S. .

GASTROENTEROLOGY, 2012, 142 (04) :1021-U552

[4]

Arai Y, 2013, HEPATOLOGY

[5] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[6] gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis [J].

Bollrath, Julia ;

Phesse, Toby J. ;

von Burstin, Vivian A. ;

Putoczki, Tracy ;

Bennecke, Moritz ;

Bateman, Trudie ;

Nebelsiek, Tim ;

Lundgren-May, Therese ;

Canli, Oezge ;

Schwitalla, Sarah ;

Matthews, Vance ;

Schmid, Roland M. ;

Kirchner, Thomas ;

Arkan, Melek C. ;

Ernst, Matthias ;

Greten, Florian R. .

CANCER CELL, 2009, 15 (02) :91-102

[7] Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping [J].

Borger, Darrell R. ;

Tanabe, Kenneth K. ;

Fan, Kenneth C. ;

Lopez, Hector U. ;

Fantin, Valeria R. ;

Straley, Kimberly S. ;

Schenkein, David P. ;

Hezel, Aram F. ;

Ancukiewicz, Marek ;

Liebman, Hannah M. ;

Kwak, Eunice L. ;

Clark, Jeffrey W. ;

Ryan, David P. ;

Deshpande, Vikram ;

Dias-Santagata, Dora ;

Ellisen, Leif W. ;

Zhu, Andrew X. ;

Iafrate, A. John .

ONCOLOGIST, 2012, 17 (01) :72-79

[8] Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy [J].

Cheon, Young Koog ;

Cho, Young Deok ;

Moon, Jong Ho ;

Jang, Jae Young ;

Kim, Young Seok ;

Kim, Yun Soo ;

Lee, Moon Sung ;

Lee, Joon Seong ;

Shim, Chan Sup .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (10) :2164-2170

[9] Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells [J].

Corcoran, Ryan B. ;

Scott, Matthew P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (22) :8408-8413

[10] Oxysterols pathway in are novel activators of the hedgehog pluripotent mesenchymal cells [J].

Dwyer, Jennifer R. ;

Sever, Navdar ;

Carlson, Marc ;

Nelson, Stanley F. ;

Beachy, Philip A. ;

Parhami, Farhad .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (12) :8959-8968

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