Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China

被引：14

作者：

Zhong, Jing ^{[1
,2
]}

Liang, Lijun ^{[1
,3
]}

Huang, Ping ^{[1
,3
]}

Zhu, Xiaolan ^{[1
]}

Zou, Lirong ^{[1
]}

Yu, Shouyi ^{[4
]}

Zhang, Xin ^{[1
]}

Zhang, Yonghui ^{[1
]}

Ni, Hanzhong ^{[1
]}

Yan, Jin ^{[1
]}

机构：

[1] Guangdong Prov Ctr Dis Control & Prevent, Key Lab Emergency Pathogen Detect, Guangzhou 511430, Guangdong, Peoples R China

[2] Guangzhou Chest Hosp, Dept Infect Dis, Guangzhou 510095, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou 510080, Guangdong, Peoples R China

[4] Southern Med Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, Guangzhou 510515, Guangdong, Peoples R China

来源：

VIROLOGY JOURNAL | 2013年 / 10卷

基金：

中国国家自然科学基金;

关键词：

Influenza; H3N2; Phylogenetics; Mutation; Epidemic; A VIRUSES; HEMAGGLUTININ; EVOLUTION; GLYCOSYLATION; VARIABILITY; PROTEIN; H1N1;

D O I：

10.1186/1743-422X-10-345

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: An influenza H3N2 epidemic occurred throughout Southern China in 2012. Methods: We analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011-2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylation within these strains were analyzed. Results: The 2011-2012 Guangdong strains contained the HA-A214S, HA-V239I, HA-N328S, NA-L81P, and NA-D93G mutations, similar to those seen in the A/Perth/16/2009 influenza strain. The HA-NSS061-063 and NNS160-162 glycosylation sites were prevalent among the 2011-2012 Guangdong strains but the NA-NRS402-404 site was deleted. Antigenically, there was a four-fold difference between A/Perth/16/2009 -like strains and the 2011-2012 Guangdong strains. Conclusion: Antigenic drift of the H3N2 subtype contributed to the occurrence of the Southern China influenza epidemic of 2012.

引用

页数：7

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