A biocompatible PAA-Cu-MOP hydrogel for wound healing

被引：19
作者：
Chen, Linlin [1 ]
Qin, Yu [2 ]
Cheng, Jing [3 ]
Cheng, Yi [2 ]
Lu, Zhixiang [2 ]
Liu, Xiaolan [2 ]
Yang, Shaoxiong [2 ]
Lu, Shuhan [2 ]
Zheng, Liyan [2 ]
Cao, Qiue [2 ]
机构：
[1] QuanZhou Med Coll, Sch Pharm, Quanzhou 362000, Fujian, Peoples R China
[2] Yunnan Univ, Funct Mol Anal & Biotransformat Key Lab Univ Yunn, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China
[3] Quanzhou Med Coll, Dept Basic Med, Quanzhou 362000, Fujian, Peoples R China
来源：
RSC ADVANCES | 2020年 / 10卷 / 59期
基金：
中国国家自然科学基金;
关键词：
ENDOTHELIAL GROWTH-FACTOR; GLUCOSE-OXIDASE; COPPER; RELEASE; TISSUE; PHASE; MODEL; ACID; IMMOBILIZATION; HYGROSCOPICITY;
D O I：
10.1039/c9ra10031h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Wounds infected by bacteria are dangerous for human beings. However, along with the emergence of new strains and strong bacterial resistance, traditional antibiotics are unable to meet the medical needs for treating bacterial infections. Thus, new antibacterial substances with superior antimicrobial properties are urgently needed. Herein, a hydrogel containing poly acrylic acid (PAA), glycerol and Cu-MOP (named PAA-Cu-MOP hydrogel) is obtained by a facile mixing and ultrasonic procedure for wound healing treatment. This PAA-Cu-MOP hydrogel with high biocompatibility exhibits excellent wound healing behavior and is even better than the one of recombinant human epidermal growth factor. Tissue experiment results reveal that the PAA-Cu-MOP hydrogel accelerates the wound healing process by promoting angiogenesis, stimulating cell proliferation, and up-regulating cell factors.
引用
收藏
页码：36212 / 36218
页数：7
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