Favorable outcome with hemoperfusion of polymyxin B-immobilized fiber column for rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis: report of three cases

被引：28

作者：

Ichiyasu, Hidenori ^{[1
]}

Horio, Yuko ^{[1
]}

Tsumura, Shinsuke ^{[1
]}

Hirosako, Susumu ^{[1
]}

Sakamoto, Yasumiko ^{[1
]}

Sakata, Shinya ^{[1
]}

Nakashima, Kei ^{[1
]}

Komatsu, Taiyo ^{[1
]}

Kojima, Keisuke ^{[1
]}

Masunaga, Aiko ^{[1
]}

Fujii, Kazuhiko ^{[1
]}

Saita, Naoki ^{[1
]}

Kohrogi, Hirotsugu ^{[1
]}

机构：

[1] Kumamoto Univ, Kumamoto Univ Hosp, Fac Life Sci, Dept Resp Med, Kumamoto 8608556, Japan

来源：

MODERN RHEUMATOLOGY | 2014年 / 24卷 / 02期

关键词：

Clinically amyopathic dermatomyositis; Direct hemoperfusion of polymyxin B-immobilized fiber column; KL-6; Rapidly progressive interstitial pneumonia; IDIOPATHIC PULMONARY-FIBROSIS; ACUTE EXACERBATION; LUNG-DISEASE; POLYMYOSITIS; SEPSIS;

D O I：

10.3109/14397595.2013.852847

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present 3 cases of rapidly progressive interstitial pneumonia (RPIP) associated with clinically amyopathic dermatomyositis (C-ADM) that were treated with two courses of direct hemo-perfusion with polymyxin B-immobilized fiber column (PMX-DHP). Despite initial treatment with high-dose corticosteroids, pulsed cyclophosphamide, and cyclosporine, the lung disease and hypoxemia deteriorated in all the patients. After PMX-DHP treatment, the PaO2/FiO(2) ratio and serum LDH and KL-6 were improved, the abnormal shadows in chest high-resolution computed tomography (HRCT) scans gradually decreased, and, finally, all patients survived. These findings indicate that PMX-DHP treatment could be effective in the management of RPIP in patients with C-ADM in combination with conventional therapy.

引用

页码：361 / 365

页数：5

共 15 条

[11] Endotoxin apheresis for sepsis [J].

Shimizu, Tomoharu ;

Endo, Yoshihiro ;

Tsuchihashi, Hiroshi ;

Akabori, Hiroya ;

Yamamoto, Hiroshi ;

Tani, Tohru .

TRANSFUSION AND APHERESIS SCIENCE, 2006, 35 (03) :271-282

[12] Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis sine myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness? [J].

Sontheimer, RD .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2002, 46 (04) :626-636

[13] Interstitial lung diseases associated with amyopathic dermatomyositis [J].

Suda, T. ;

Fujisawa, T. ;

Enomoto, N. ;

Nakamura, Y. ;

Inui, N. ;

Naito, T. ;

Hashimoto, D. ;

Sato, J. ;

Toyoshima, M. ;

Hashizume, H. ;

Chida, K. .

EUROPEAN RESPIRATORY JOURNAL, 2006, 28 (05) :1005-1012

[14] Effects of PMX-DHP treatment for patients with directly induced acute respiratory distress syndrome [J].

Tsushima, Kenji ;

Kubo, Keishi ;

Yoshikawa, Sumiko ;

Koizumi, Tomonobu ;

Yasuo, Masanori ;

Furuya, Shino ;

Hora, Kazuhiko .

THERAPEUTIC APHERESIS AND DIALYSIS, 2007, 11 (02) :138-145

[15] Polymyxin B-immobilized Fiber Column Hemoperfusion Treatment for Drug-Induced Severe Respiratory Failure: Report of Three Cases [J].

Yokoyama, Toshiki ;

Tsushima, Kenji ;

Yamamoto, Hiroshi ;

Ito, Michiko ;

Agatsuma, Toshihiko ;

Kozumi, Tomonobu ;

Kubo, Keishi .

INTERNAL MEDICINE, 2010, 49 (01) :59-64

← 1 2 →