Favorable outcome with hemoperfusion of polymyxin B-immobilized fiber column for rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis: report of three cases

被引：28

作者：

Ichiyasu, Hidenori ^{[1
]}

Horio, Yuko ^{[1
]}

Tsumura, Shinsuke ^{[1
]}

Hirosako, Susumu ^{[1
]}

Sakamoto, Yasumiko ^{[1
]}

Sakata, Shinya ^{[1
]}

Nakashima, Kei ^{[1
]}

Komatsu, Taiyo ^{[1
]}

Kojima, Keisuke ^{[1
]}

Masunaga, Aiko ^{[1
]}

Fujii, Kazuhiko ^{[1
]}

Saita, Naoki ^{[1
]}

Kohrogi, Hirotsugu ^{[1
]}

机构：

[1] Kumamoto Univ, Kumamoto Univ Hosp, Fac Life Sci, Dept Resp Med, Kumamoto 8608556, Japan

来源：

MODERN RHEUMATOLOGY | 2014年 / 24卷 / 02期

关键词：

Clinically amyopathic dermatomyositis; Direct hemoperfusion of polymyxin B-immobilized fiber column; KL-6; Rapidly progressive interstitial pneumonia; IDIOPATHIC PULMONARY-FIBROSIS; ACUTE EXACERBATION; LUNG-DISEASE; POLYMYOSITIS; SEPSIS;

D O I：

10.3109/14397595.2013.852847

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present 3 cases of rapidly progressive interstitial pneumonia (RPIP) associated with clinically amyopathic dermatomyositis (C-ADM) that were treated with two courses of direct hemo-perfusion with polymyxin B-immobilized fiber column (PMX-DHP). Despite initial treatment with high-dose corticosteroids, pulsed cyclophosphamide, and cyclosporine, the lung disease and hypoxemia deteriorated in all the patients. After PMX-DHP treatment, the PaO2/FiO(2) ratio and serum LDH and KL-6 were improved, the abnormal shadows in chest high-resolution computed tomography (HRCT) scans gradually decreased, and, finally, all patients survived. These findings indicate that PMX-DHP treatment could be effective in the management of RPIP in patients with C-ADM in combination with conventional therapy.

引用

页码：361 / 365

页数：5

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