Cell Fate Decisions During Preimplantation Mammalian Development

被引:10
作者
Bissiere, Stephanie [1 ]
Gasnier, Maxime [1 ]
Alvarez, Yanina D. [1 ,2 ]
Plachta, Nicolas [1 ,3 ]
机构
[1] ASTAR, Inst Mol & Cell Biol, Singapore, Singapore
[2] Univ Buenos Aires, CONICET, Fac Ciencias Exactas & Nat, Buenos Aires, DF, Argentina
[3] Natl Univ Singapore, Singapore, Singapore
来源
CELL FATE IN MAMMALIAN DEVELOPMENT | 2018年 / 128卷
基金
英国惠康基金;
关键词
EMBRYONIC STEM-CELLS; RNA-POLYMERASE-II; FLUORESCENCE CORRELATION SPECTROSCOPY; STAGE MOUSE BLASTOMERES; DNA-BINDING PROTEINS; GENE-EXPRESSION; SINGLE CELLS; LIVING CELLS; E-CADHERIN; IN-VIVO;
D O I
10.1016/bs.ctdb.2017.11.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The early mouse embryo offers a phenomenal system to dissect how changes in the mechanisms controlling cell fate are integrated with morphogenetic events at the single-cell level. New technologies based on live imaging have enabled the discovery of dynamic changes in the regulation of single genes, transcription factors, and epigenetic mechanisms directing early cell fate decision in the early embryo. Here, we review recent progress in linking molecular dynamic events occurring at the level of the single cell in vivo, to some of the key morphogenetic changes regulating early mouse development.
引用
收藏
页码:37 / 58
页数:22
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