African swine fever virus (ASFV) protection mediated by NH/P68 and NH/P68 recombinant live-attenuated viruses

被引：169

作者：

Gallardo, Carmina ^{[2
]}

Sanchez, Elena G. ^{[1
]}

Perez-Nunez, Daniel ^{[1
]}

Nogal, Marisa ^{[1
]}

de Leon, Patricia ^{[1
]}

Carrascosa, Angel L. ^{[1
]}

Nieto, Raquel ^{[2
]}

Soler, Alejandro ^{[2
]}

Luisa Arias, Maria ^{[2
]}

Revilla, Yolanda ^{[1
]}

机构：

[1] UAM, CSIC, Ctr Biol Mol Severo Ochoa, Virol Dept, Madrid 28049, Spain

[2] Ctr Invest Sanidad Anim INIA CISA, European Union Reference Lab ASF, Madrid, Spain

来源：

VACCINE | 2018年 / 36卷 / 19期

关键词：

ASFV; Recombinants; Deletion mutants; LAVs; NH/P68; Armenia07/Arm07; ISOLATE HARBORING DELETIONS; NUCLEAR-FACTOR; NEUTRALIZING ANTIBODIES; CONFER PROTECTION; DOMESTIC PIGS; KAPPA-B; ACTIVATION; INHIBITION; EXPRESSION; CHALLENGE;

D O I：

10.1016/j.vaccine.2018.03.040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The risk of spread of African swine fever virus (ASFV) from Russia and Caucasian areas to several EU countries has recently emerged, making it imperative to improve our knowledge and defensive tools against this important pathogen. The ASFV genome encodes many genes which are not essential for virus replication but are known to control host immune evasion, such as NFxB and the NFAT regulator A238L, the apoptosis inhibitor A224L, the MHC-I antigen presenting modulator EP153R, and the A276R gene, involved in modulating type I IFN. These genes are hypothesized to be involved in virulence of the genotype I parental ASFV NH/P68. We here describe the generation of putative live attenuated vaccines (LAV) prototypes by constructing recombinant NH/P68 viruses lacking these specific genes and containing specific markers. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：2694 / 2704

页数：11

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