CD34 and α smooth muscle actin distinguish verrucous hyperplasia from verrucous carcinoma

被引：12
作者：
Paral, Kristen M. [1 ]
Taxy, Jerome B. [2 ]
Lingen, Mark W. [1 ]
机构：
[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[2] NorthShore Univ Hlth Syst, Dept Pathol, Evanston, IL USA
来源：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2014年 / 117卷 / 04期
关键词：
SQUAMOUS-CELL CARCINOMA; BREAST-LESIONS; STROMAL CELLS; ORAL-CAVITY; DNA-PLOIDY; IN-SITU; LEUKOPLAKIA; EXPRESSION; FIBROCYTES; MYOFIBROBLASTS;
D O I：
10.1016/j.oooo.2013.12.401
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objective. This study evaluated the use of stromal biomarkers CD34 and alpha smooth muscle actin (alpha-SMA) to distinguish verrucous carcinoma (VC) from verrucous hyperplasia (VH). Study Design. Thirteen VH, 15 VC, 20 squamous cell carcinoma (SCC), and 16 of uninvolved adjacent stroma specimens were analyzed for alpha-SMA and CD34 expression by immunohistochemistry. Results. Stromal alpha-SMA positivity was observed in 100% (20 of 20) of the SCC and in 93% (14 of 15) of the VC, whereas none of the VH (0 of 13) or adjacent uninvolved stroma (0 of 16) demonstrated alpha-SMA reactivity. Stromal CD34 positivity was observed in 100% (13 of 13) of VH and adjacent stroma (16 of 16), while 20% (3 of 15) of VC and 11% (2 of 18) of SCC stroma expressed CD34. The SCC and VC groups differed significantly from the VH and uninvolved stroma groups for both alpha-SMA and CD34 expression (P <.0001). Conclusions. Stromal CD34 and alpha-SMA protein expression patterns may aid in distinguishing between VC and VH in challenging cases.
引用
收藏
页码：477 / 482
页数：6
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