Regulation of bone marrow mesenchymal stem cell fate by long non-coding RNA

被引：19
|
作者：
Guo, Qiaoyue [1 ]
Guo, Qi [1 ]
Xiao, Ye [1 ]
Li, Changjun [1 ]
Huang, Yan [1 ]
Luo, Xianghang [1 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Endocrinol Res Ctr, Dept Endocrinol, 87 Xiangya Rd, Changsha, Hunan, Peoples R China
来源：
BONE | 2020年 / 141卷
关键词：
BMSCs; LncRNA; Osteogenesis; Adipogenesis; Signaling pathway; Biomarker; PROMOTES OSTEOGENIC DIFFERENTIATION; COMPETING ENDOGENOUS RNA; PPAR-GAMMA; CHONDROGENIC DIFFERENTIATION; OSTEOBLAST DIFFERENTIATION; UP-REGULATION; NOTCH; ADIPOGENESIS; WNT; PROLIFERATION;
D O I：
10.1016/j.bone.2020.115617
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bone mesenchymal stem cells (BMSCs) are progenitor cells isolated from bone marrow, which keep potential to differentiate into several kinds of cells including osteoblasts and adipocytes. A dynamic mutual regulation exists between osteogenesis and adipogenesis processes. Long non-coding RNA (lncRNA) performs diverse functions in biological activities including regulation of BMSCs commitment. Evidence has shown that lncRNA regulates key signaling pathways including TGF beta/BMP, Wnt and Notch pathways, and several transcription factors in BMSCs differention. Dysregulation of lncRNA in BMSCs leads to disruption of osteo-adipogenesis difffrentiation and results in impairment of bone homeostasis. In this review, we focus on the role of lncRNA in several critical signaling pathways that involved in regulation of osteo-adipogenesis of BMSC and prospects the potential clinical application of lncRNA.
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页数：11
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