TFBS: Computational framework for transcription factor binding site analysis

被引:132
作者
Lenhard, B [1 ]
Wasserman, WW [1 ]
机构
[1] Karolinska Inst, Ctr Genom & Bioinformat, Bioinformat Unit, Stockholm, Sweden
关键词
D O I
10.1093/bioinformatics/18.8.1135
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
TFBS is a set of integrated, object-oriented Perl modules for transcription factor binding site detection and analysis. It implements objects representing specificity profile matrices, binding sites and sets thereof, pattern generators, and pattern database interfaces. The modules are interoperable with the BioPerl open source system.
引用
收藏
页码:1135 / 1136
页数:2
相关论文
共 8 条
[1]  
Arnone MI, 1997, DEVELOPMENT, V124, P1851
[2]   SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS [J].
BERG, OG ;
VONHIPPEL, PH .
TRENDS IN BIOCHEMICAL SCIENCES, 1988, 13 (06) :207-211
[3]   A novel method to develop highly specific models for regulatory units detects a new LTR in GenBank which contains a functional promoter [J].
Frech, K ;
DanescuMayer, J ;
Werner, T .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 270 (05) :674-687
[4]   A predictive model for regulatory sequences directing liver-specific transcription [J].
Krivan, W ;
Wasserman, WW .
GENOME RESEARCH, 2001, 11 (09) :1559-1566
[5]   DETECTING SUBTLE SEQUENCE SIGNALS - A GIBBS SAMPLING STRATEGY FOR MULTIPLE ALIGNMENT [J].
LAWRENCE, CE ;
ALTSCHUL, SF ;
BOGUSKI, MS ;
LIU, JS ;
NEUWALD, AF ;
WOOTTON, JC .
SCIENCE, 1993, 262 (5131) :208-214
[6]   SEQUENCE LOGOS - A NEW WAY TO DISPLAY CONSENSUS SEQUENCES [J].
SCHNEIDER, TD ;
STEPHENS, RM .
NUCLEIC ACIDS RESEARCH, 1990, 18 (20) :6097-6100
[7]  
STADEN R, 1990, METHOD ENZYMOL, V183, P193
[8]   Identification of regulatory regions which confer muscle-specific gene expression [J].
Wasserman, WW ;
Fickett, JW .
JOURNAL OF MOLECULAR BIOLOGY, 1998, 278 (01) :167-181