Highly enantioselective fluoromalonate addition to α,β-unsaturated aldehydes

被引：59
作者：
Companyo, Xavier [2 ]
Hejnova, Monika [1 ]
Kamlar, Martin [1 ]
Vesely, Jan [1 ]
Moyano, Albert [2 ]
Rios, Ramon [2 ,3 ]
机构：
[1] Charles Univ Prague, Dept Organ Chem, Prague 12800, Czech Republic
[2] Univ Barcelona, Dept Quim Organ, Fac Quim, E-08028 Barcelona, Catalonia, Spain
[3] Passeig Lluis Co, Catalan Inst Res & Adv Studies ICREA, Barcelona 08018, Castalonia, Spain
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 35期
关键词：
ONE-POT; FLUORINATED SULFONES; CONJUGATE ADDITION; ALPHA-FLUORINATION; ASYMMETRIC ENTRY; EPOXIDATION; ALKYLATION; CHEMISTRY;
D O I：
10.1016/j.tetlet.2009.06.092
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly enantioselective organocatalytic fluoromalonate addition to alpha,beta-unsaturatecl aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding 1,4-adducts with high yields and enantioselectivities. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5021 / 5024
页数：4
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