A divergent approach to the myriaporones and tedanolide: Completion of the carbon skeleton of myriaporone 1

被引：51

作者：

Taylor, RE

Hearn, BR

Ciavarri, JP

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

[2] Univ Notre Dame, Walther Canc Ctr, Notre Dame, IN 46556 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 17期

关键词：

D O I：

10.1021/ol026356s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A linear but concise synthetic approach toward the structurally related natural products myriaporone and tedanolide is reported. The route is highlighted by a stereoselective homoallenylboration and a regio- and chemoselective nitrile oxide cycloaddition. Installation of the (Z)-olefin completed the carbon skeleton of myriaporone 1.

引用

页码：2953 / 2955

页数：3

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