Transforming growth factor-β1 in regulatory T cell biology

被引：160

作者：

Moreau, Joshua M. ^{[1
]}

Velegraki, Maria ^{[2
]}

Bolyard, Chelsea ^{[2
]}

Rosenblum, Michael D. ^{[1
]}

Li, Zihai ^{[2
]}

机构：

[1] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94118 USA

[2] Ohio State Univ, Pelotonia Inst Immunooncol, Comprehens Canc Ctr, James Canc Hosp, Columbus, OH 43210 USA

来源：

SCIENCE IMMUNOLOGY | 2022年 / 7卷 / 69期

关键词：

GROWTH-FACTOR-BETA; LATENT TGF-BETA; FOXP3; EXPRESSION; IN-VIVO; SUPPRESSOR FUNCTION; SURFACE EXPRESSION; IMMUNE TOLERANCE; BINDING-PROTEIN; CIS-ELEMENT; TGF-BETA-1;

D O I：

10.1126/sciimmunol.abi4613

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transforming growth factor-beta 1 (TGF-beta 1) is inextricably linked to regulatory T cell (T-reg) biology. However, precisely untangling the role for TGF-beta 1 in T-reg differentiation and function is complicated by the pleiotropic and context-dependent activity of this cytokine and the multifaceted biology of T-reg. Among CD4(+) T cells, T-reg are the major producers of latent TGF-beta 1 and are uniquely able to activate this cytokine via expression of cell surface docking receptor glycoprotein A repetitions predominant (GARP) and alpha v integrins. Although a preponderance of evidence indicates no essential roles for T-reg-derived TGF-beta 1 in T reg immunosuppression, TGF-beta 1 signaling is crucial for T-reg development in the thymus and periphery. Furthermore, active TGF-beta 1 instructs the differentiation of other T cell subsets, including T(H)17 cells. Here, we will review TGF-beta 1 signaling in T-reg development and function and discuss knowledge gaps, future research, and the TGF-beta 1 /T-reg axis in the context of cancer immunotherapy and fibrosis.

引用

页数：13

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