Heterocycles of biological importance:: Part 8.: Formation of pyrimido[1,2-a]benzimidazoles and oxazolo[3,2-a]benzimidazoles by conjugate addition of 2-aminobenzimidazoles to 4-hydroxy-2-alkynenitriles

被引：18

作者：

Wahe, H

Asobo, PF

Cherkasov, RA

Fomum, ZT

Doepp, D ^{[1
]}

机构：

[1] Univ Duisburg Essen, Inst Chem, D-47048 Duisburg, Germany

[2] Kazan VI Lenin State Univ, Dept Chem, Kazan 48008, Russia

[3] Univ Yaounde, Dept Organ Chem, Yaounde, Cameroon

来源：

ARKIVOC | 2004年

关键词：

fused imidazoles; fused pyrimidines; fused oxazoles; pharmaceuticals;

D O I：

10.3998/ark.5550190.0005.112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Aminobenzimidazole (1a) and its 5,6-dimethyl derivative 1b react with 4-hydroxy-2-alkynenitriles 2a-d in ethanol under reflux to give 2-amino-4-(1'-hydroxyalkyl) pyrimido[ 1,2-a]benzimidazoles 5a-e and in dimethylformamide at 155 degreesC to give (2,2-dialkyl-2,3-dihydrooxazolo[ 3,2-a] benzimidazolylidene) ethanenitriles 7a-e.

引用

页码：130 / 137

页数：8

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