New MCR based on intramolecular Heck reaction under aerobic conditions: a direct access to cytotoxic fused N-heterocycles

被引：14

作者：

Adepu, Raju ^{[1
]}

Prasad, Bagineni ^{[1
]}

Ashfaq, Mohd Ashraf ^{[1
]}

Ehtesham, Nasreen Z. ^{[1
]}

Pal, Manojit ^{[1
]}

机构：

[1] Dr Reddys Inst Life Sci, Hyderabad 500046, Andhra Pradesh, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 90期

关键词：

RUTAECARPINE; QUINAZOLONES; DERIVATIVES; QUINOLINES; CASCADE; AMINES; ASSAY; MILD; UGI;

D O I：

10.1039/c4ra10702k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a new MCR involving the reaction of isatoic anhydrides, allyl amine and o-bromo arylaldehydes in the presence of Pd(OAc)(2), X-Phos and air to afford various isoquinolino[1,2-b]quinazolinones as new cytotoxic agents. The strategy was extended successfully towards the synthesis of a methyl analogue of 7,8-dehydrorutaecarpine.

引用

页码：49324 / 49328

页数：5

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