Future Directions for Dementia Risk Reduction and Prevention Research: An International Research Network on Dementia Prevention Consensus

被引：26

作者：

Anstey, Kaarin J. ^{[1
,2
]}

Peters, Ruth ^{[1
,2
]}

Zheng, Lidan ^{[1
,2
]}

Barnes, Deborah E. ^{[3
,4
,5
]}

Brayne, Carol ^{[6
]}

Brodaty, Henry ^{[7
]}

Chalmers, John ^{[8
]}

Clare, Linda ^{[9
]}

Dixon, Roger A. ^{[10
]}

Dodge, Hiroko ^{[11
,12
,13
]}

Lautenschlager, Nicola T. ^{[14
,15
]}

Middleton, Laura E. ^{[16
]}

Qiu, Chengxuan ^{[17
,18
]}

Rees, Glenn

Shahar, Suzana

Yaffe, Kristine ^{[3
,4
,5
]}

机构：

[1] Univ New South Wales, AUNSW Aging Futures Inst, Sch Psychol, Sydney, NSW, Australia

[2] Neurosci Res Australia NeuRA, Randwick, NSW, Australia

[3] Univ Calif San Francisco, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[5] San Francisco Vet Affairs Hlth Care Syst, San Francisco, CA USA

[6] Univ Cambridge, Cambridge Publ Hlth, Forvie Site, Cambridge, England

[7] Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia

[8] Univ New South Wales, George Inst Global Hlth, Fac Med, Sydney, NSW, Australia

[9] Univ Exeter, Coll Med & Hlth, St Lukes Campus, Exeter, Devon, England

[10] Univ Alberta, Neurosci & Mental Hlth Inst, Dept Psychol, Edmonton, AB, Canada

[11] Oregon Hlth & Sci Univ, Dept Neurol, Layton Aging & Alzheimers Dis Ctr, Portland, OR 97201 USA

[12] Univ Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA

[13] Univ Michigan, Michigan Alzheimers Dis Ctr, Ann Arbor, MI 48109 USA

[14] Univ Melbourne, Dept Psychiat, Acad Unit Psychiat Old Age, Parkville, Vic, Australia

[15] Royal Melbourne Hosp, NorthWestern Mental Hlth, Parkville, Vic, Australia

[16] Univ Waterloo, Dept Kinesiol, Waterloo, ON, Canada

[17] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Solna, Sweden

[18] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Solna, Sweden

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2020年 / 78卷 / 01期

基金：

瑞典研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

Multi-domain; primary prevention; risk factor; risk reduction; ALZHEIMERS-DISEASE; COGNITIVE FUNCTION; OLDER-ADULTS; EPIDEMIOLOGY;

D O I：

10.3233/JAD-200674

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the past decade a large body of evidence has accumulated on risk factors for dementia, primarily from Europe and North America. Drawing on recent integrative reviews and a consensus workshop, the International Research Network on Dementia Prevention developed a consensus statement on priorities for future research. Significant gaps in geographical location, representativeness, diversity, duration, mechanisms, and research on combinations of risk factors were identified. Future research to inform dementia risk reduction should fill gaps in the evidence base, take a life-course, multi-domain approach, and inform population health approaches that improve the brain-health of whole communities.

引用

页码：3 / 12

页数：10

共 49 条

[1]

[Anonymous], 2019, NUTRIENTS

[2] A Systematic Review of Meta-Analyses that Evaluate Risk Factors for Dementia to Evaluate the Quantity, Quality, and Global Representativeness of Evidence [J].

Anstey, Kaarin J. ;

Ee, Nicole ;

Eramudugolla, Ranmalee ;

Jagger, Carol ;

Peters, Ruth .

JOURNAL OF ALZHEIMERS DISEASE, 2019, 70 :S165-S186

[3] Joining forces to prevent dementia: The International Research Network On Dementia Prevention (IRNDP) [J].

Anstey, Kaarin J. ;

Peters, Ruth ;

Clare, Linda ;

Lautenschlager, Nicola T. ;

Dodge, Hiroko H. ;

Barnes, Deborah E. ;

Shahar, Suzana ;

Brodaty, Henry ;

Rees, Glenn .

INTERNATIONAL PSYCHOGERIATRICS, 2017, 29 (11) :1757-1760

[4] Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need [J].

Babulal, Ganesh M. ;

Quiroz, Yakeel T. ;

Albensi, Benedict C. ;

Arenaza-Urquijo, Eider ;

Astell, Arlene J. ;

Babiloni, Claudio ;

Bahar-Fuchs, Alex ;

Bell, Joanne ;

Bowman, Gene L. ;

Brickman, Adam M. ;

Chetelat, Gael ;

Ciro, Carrie ;

Cohen, Ann D. ;

Dilworth-Anderson, Peggye ;

Dodge, Hiroko H. ;

Dreux, Simone ;

Edland, Steven ;

Esbensen, Anna ;

Evered, Lisbeth ;

Ewers, Michael ;

Fargo, Keith N. ;

Fortea, Juan ;

Gonzalez, Hector ;

Gustafson, Deborah R. ;

Head, Elizabeth ;

Hendrix, James A. ;

Hofer, Scott M. ;

Johnson, Leigh A. ;

Jutten, Roos ;

Kilborn, Kerry ;

Lanctot, Krista L. ;

Manly, Jennifer J. ;

Martins, Ralph N. ;

Mielke, Michelle M. ;

Morris, Martha Clare ;

Murray, Melissa E. ;

Oh, Esther S. ;

Parra, Mario A. ;

Rissman, Robert A. ;

Roe, Catherine M. ;

Santos, Octavio A. ;

Scarmeas, Nikolaos ;

Schneider, Lon S. ;

Schupf, Nicole ;

Sikkes, Sietske ;

Snyder, Heather M. ;

Sohrabi, Hamid R. ;

Stern, Yaakov ;

Strydom, Andre ;

Tang, Yi .

ALZHEIMERS & DEMENTIA, 2019, 15 (02) :292-312

[5] A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap [J].

Badhwar, AmanPreet ;

McFall, G. Peggy ;

Sapkota, Shraddha ;

Black, Sandra E. ;

Chertkow, Howard ;

Duchesne, Simon ;

Masellis, Mario ;

Li, Liang ;

Dixon, Roger A. ;

Bellec, Pierre .

BRAIN, 2020, 143 :1315-1331

[6] The projected effect of risk factor reduction on Alzheimer's disease prevalence [J].

Barnes, Deborah E. ;

Yaffe, Kristine .

LANCET NEUROLOGY, 2011, 10 (09) :819-828

[7] The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model [J].

Bateman, Randall J. ;

Benzinger, Tammie L. ;

Berry, Scott ;

Clifford, David B. ;

Duggan, Cynthia ;

Fagan, Anne M. ;

Fanning, Kathleen ;

Farlow, Martin R. ;

Hassenstab, Jason ;

McDade, Eric M. ;

Mills, Susan ;

Paumier, Katrina ;

Quintana, Melanie ;

Salloway, Stephen P. ;

Santacruz, Anna ;

Schneider, Lon S. ;

Wang, Guoqiao ;

Xiong, Chengjie .

ALZHEIMERS & DEMENTIA, 2017, 13 (01) :8-19

[8] Epidemiology of Obesity and Diabetes and Their Cardiovascular Complications [J].

Bhupathiraju, Shilpa N. ;

Hu, Frank B. .

CIRCULATION RESEARCH, 2016, 118 (11) :1723-1735

[9] Prevention of Cognitive Decline: A Goal in Sight? [J].

Brayne, Carol ;

Richard, Edo .

JOURNAL OF ALZHEIMERS DISEASE, 2019, 70 :S11-S14

[10] Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration [J].

Casaletto, K. B. ;

Staffaroni, A. M. ;

Wolf, A. ;

Appleby, B. ;

Brushaber, D. ;

Coppola, G. ;

Dickerson, B. ;

Domoto-Reilly, K. ;

Elahi, F. M. ;

Fields, J. ;

Fong, J. C. ;

Forsberg, L. ;

Ghoshal, N. ;

Graff-Radford, N. ;

Grossman, M. ;

Heuer, H. W. ;

Hsiung, G. -Y. ;

Huey, E. D. ;

Irwin, D. ;

Kantarci, K. ;

Kaufer, D. ;

Kerwin, D. ;

Knopman, D. ;

Kornak, J. ;

Kramer, J. H. ;

Litvan, I. ;

Mackenzie, I. R. ;

Mendez, M. ;

Miller, B. ;

Rademakers, R. ;

Ramos, E. M. ;

Rascovsky, K. ;

Roberson, E. D. ;

Syrjanen, J. A. ;

Tartaglia, M. C. ;

Weintraub, S. ;

Boeve, B. ;

Boxer, A. L. ;

Rosen, H. ;

Yaffe, K. .

ALZHEIMERS & DEMENTIA, 2020, 16 (01) :91-105

← 1 2 3 4 5 →