A Flexible Solution to Anion Transport: Powerful Anionophores Based on a Cyclohexane Scaffold

被引：51

作者：

Cooper, James A. ^{[1
]}

Street, Steven T. G. ^{[1
]}

Davis, Anthony P. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

anion binding; anion transport; molecular recognition; receptors; supramolecular chemistry; CHLORIDE TRANSPORT; PROTONATION CONSTANTS; SYNTHETIC IONOPHORE; RECEPTORS; BINDING; SELECTIVITY; MEMBRANES; ASSAY; NMR;

D O I：

10.1002/anie.201311071

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transmembrane anion carriers (anionophores) have potential for biological activity, including the treatment of channelopathies such as cystic fibrosis. A new family of anionophores has been synthesized, in which three thiourea groups are mounted on a cyclohexane-based scaffold. Though conceptually related to earlier polycyclic systems, these molecules are simpler and far more accessible. Preorganization is somewhat reduced compared to earlier systems, and anion affinities are correspondingly lower. However, transport activities set new records. This surprising performance suggests a role for controlled flexibility in the design of transmembrane anion carriers.

引用

页码：5609 / 5613

页数：5

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