The potential utility of chitosan micro/nanoparticles in the treatment of gastric infection

被引:42
作者
Goncalves, Ines C. [1 ,3 ]
Henriques, Patricia C. [1 ,3 ]
Seabra, Catarina L. [1 ,2 ,4 ]
Martins, M. Cristina L. [1 ,4 ]
机构
[1] Univ Porto, INEB Inst Engn Biomed, P-4150180 Oporto, Portugal
[2] Univ Porto, IPATIMUP Inst Mol Pathol & Immunol, P-4200465 Oporto, Portugal
[3] Univ Porto, Fac Engn, P-4100 Oporto, Portugal
[4] Univ Porto, Inst Ciencias Biomed Abel Salazar, P-4100 Oporto, Portugal
关键词
biomaterials; chitosan; crosslinking; drug delivery; gastric cancer; Helicobacter pylori; microspheres; mucoadhesion; nanoparticles; polyelectrolytes; HELICOBACTER-PYLORI INFECTION; OCCURRING CROSS-LINKER; IN-VITRO EVALUATION; DRUG-DELIVERY; POLYELECTROLYTE COMPLEXES; MUCOADHESIVE PROPERTIES; BIOMEDICAL APPLICATIONS; NANOPARTICLES; MICROSPHERES; AMOXICILLIN;
D O I
10.1586/14787210.2014.930663
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Gastric infections are mainly caused by Helicobacter pylori (H. pylori), a bacterium that colonizes the gastric mucosa of over 50% of the world's population. Chronic H. pylori infection has been associated with gastric diseases such as chronic gastritis, peptic ulcer and gastric adenocarcinoma. Current eradication treatment relies on antibiotic-based therapies that are unsuccessful in approximately 20% of the patients. Chitosan, a natural and cationic polysaccharide has been investigated in the treatment of H. pylori infection. Due to its mucoadhesive properties, it has been used in the form of micro/nanoparticles, polyelectrolyte complexes or coatings as antibiotic encapsulation systems for gastric delivery, but alternative molecules may also be incorporated. It has been recently proposed that chitosan can also be used for H. pylori binding and scavenging from the host stomach due to its antimicrobial/binding properties. In this manuscript, a brief description of the use of chitosan in H. pylori treatment is reviewed.
引用
收藏
页码:981 / 992
页数:12
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