A potent antimalarial trichothecene from hyphomycete species

被引：7

作者：

Waterman, Carrie ^{[1
]}

Calcul, Laurent ^{[1
]}

Mutka, Tina ^{[2
]}

Kyle, Dennis E. ^{[2
,3
]}

Pearce, Cedric J. ^{[4
]}

Baker, Bill J. ^{[1
,3
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Univ S Florida, Dept Global Hlth, Tampa, FL 33612 USA

[3] Univ S Florida, Ctr Drug Discovery & Innovat, Tampa, FL 33612 USA

[4] Mycosynthetix Inc, Hillsborough, NC 27278 USA

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 29期

关键词：

Hyphomycetes; High-throughput screening; Antimalarial; Sesquiterpene; Trichothecinol D; MYCOTOXINS; ANALOGS; ROSEUM;

D O I：

10.1016/j.tetlet.2014.05.056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Antimalarial screening of diverse fungal samples resulted in the isolation and identification of a new sesquiterpene, trichothecinol D (1), which exhibited potent in vitro activity against Plasmodium falciparum with a 200-fold selectivity for parasite versus mammalian cytotoxicity. Trichothecinol D was obtained by bioassay-guided fractionation of two hyphomycete species. Its chemical characterization was performed by detailed NMR spectroscopy and high resolution mass spectrometry. The absolute configuration of trichothecinol D was determined by X-ray crystallography. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3989 / 3991

页数：3

共 19 条

[1] STRUCTURE ACTIVITY STUDIES OF TRICHOTHECENES - CYTO-TOXICITY OF ANALOGS AND REACTION-PRODUCTS DERIVED FROM T-2 TOXIN AND NEOSOLANIOL [J].