Solubility of methocarbamol in some cosolvent plus water mixtures at 298.15 K and correlation with the Jouyban-Acree model

被引：40

作者：

Cardenas, Zaira J. ^{[1
]}

Jimenez, Daniel M. ^{[1
]}

Rodriguez, Gerson A. ^{[1
]}

Delgado, Daniel R. ^{[1
]}

Martinez, Fleming ^{[1
]}

Khoubnasabjafari, Maryam ^{[2
]}

Jouyban, Abolghasem ^{[3
,4
,5
]}

机构：

[1] Univ Nacl Colombia, Dept Farm, Grp Invest Farmaceut Fis Quim, Bogota, DC, Colombia

[2] Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51664, Iran

[4] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

[5] Univ Tehran, Coll Engn, Sch Chem Engn, Pharmaceut Engn Lab, Tehran, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2013年 / 188卷

关键词：

Methocarbamol; Cosolvency; Binary mixtures; Solubility; Jouyban-Acree model; SOLUTION THERMODYNAMICS; SULFAPYRIDINE; DRUGS;

D O I：

10.1016/j.molliq.2013.10.012

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Equilibrium solubility of methocarbamol was determined in binary mixtures of dioxane, polyethylene glycol 400, ethanol, methanol or propylene glycol, and water at 298.15 K. From maximum values in drug solubility and theoretical calculations involving the method proposed by Fedors a discussion was made about the Hildebrand solubility parameter for this drug. On the other hand, solubility values were correlated and/or predicted with the Jouyban-Acree model. The overall mean percentage deviations for the correlated and predicted solubilities were 2.7% and 89.0%, respectively. Finally, density of saturated and drug free solution binary solvent mixtures was also calculated using the Jouyban-Acree model. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：162 / 166

页数：5

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