The Diagnostic Value of DNA Methylation in Leukemia: A Systematic Review and Meta-Analysis

被引：42

作者：

Jiang, Danjie ^{[1
]}

Hong, Qingxiao ^{[1
]}

Shen, Yusheng ^{[1
]}

Xu, Yan ^{[1
]}

Zhu, Huangkai ^{[1
]}

Li, Yirun ^{[1
]}

Xu, Chunjing ^{[1
]}

Ouyang, Guifang ^{[2
]}

Duan, Shiwei ^{[1
]}

机构：

[1] Ningbo Univ, Sch Med, Zhejiang Prov Key Lab Pathophysiol, Ningbo 315211, Zhejiang, Peoples R China

[2] Ningbo First Hosp, Dept Hematol, Ningbo, Zhejiang, Peoples R China

来源：

PLOS ONE | 2014年 / 9卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ACUTE MYELOID-LEUKEMIA; PROMOTER METHYLATION; ABERRANT METHYLATION; TUMOR-SUPPRESSOR; B-CELL; MYELODYSPLASTIC SYNDROMES; HMLH1; PROMOTER; CPG ISLAND; GENE; EXPRESSION;

D O I：

10.1371/journal.pone.0096822

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Accumulating evidence supports a role of DNA methylation in the pathogenesis of leukemia. The aim of our study was to evaluate the potential genes with aberrant DNA methylation in the prediction of leukemia risk by a comprehensive meta-analysis of the published data. Methods: A series of meta-analyses were done among the eligible studies that were harvested after a careful filtration of the searching results from PubMed literature database. Mantel-Haenszel odds ratios and 95% confidence intervals were computed for each methylation event assuming the appropriate model. Results: A total of 535 publications were initially retrieved from PubMed literature database. After a three-step filtration, we harvested 41 case-control articles that studied the role of gene methylation in the prediction of leukemia risk. Among the involving 30 genes, 20 genes were shown to be aberrantly methylated in the leukemia patients. A further subgroup meta-analysis by subtype of leukemia showed that CDKN2A, CDKN2B, ID4 genes were significantly hypermethylated in acute myeloid leukemia. Conclusions: Our meta-analyses identified strong associations between a number of genes with aberrant DNA methylation and leukemia. Further studies should be required to confirm the results in the future.

引用

页数：7

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