Reproducibility of urinary bisphenol A concentrations measured during pregnancy in the Generation R Study

被引：23

作者：

Jusko, Todd A. ^{[1
]}

Shaw, Pamela A. ^{[2
]}

Snijder, Claudia A. ^{[3
,4
]}

Pierik, Frank H. ^{[5
]}

Koch, Holger M. ^{[6
]}

Hauser, Russ ^{[7
]}

Jaddoe, Vincent W. V. ^{[4
,8
,9
]}

Burdorf, Alex ^{[3
]}

Hofman, Albert ^{[8
]}

Tiemeier, Henning ^{[10
]}

Longnecker, Matthew R. ^{[11
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Publ Hlth Sci, Rochester, NY 14642 USA

[2] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[3] Erasmus MC, Dept Publ Hlth, NL-3000 CA Rotterdam, Netherlands

[4] Erasmus MC, Generat Study Grp R, NL-3000 CA Rotterdam, Netherlands

[5] TNO Netherlands Org Appl Sci Res, Dept Urban Environm & Safety, NL-3584 CB Utrecht, Netherlands

[6] Inst Ruhr Univ Bochum, Inst Prevent & Occupat Med German Social Accid In, D-44789 Bochum, Germany

[7] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

[8] Erasmus MC, Dept Epidemiol, NL-3000 DR Rotterdam, Netherlands

[9] Erasmus MC, Dept Pediat, NL-3000 DR Rotterdam, Netherlands

[10] Erasmus MC, Dept Child & Adolescent Psychiat, NL-3000 DR Rotterdam, Netherlands

[11] NIEHS, Epidemiol Branch, NIH, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY | 2014年 / 24卷 / 05期

基金：

美国国家卫生研究院;

关键词：

endocrine disruptor; epidemiology; environmental exposure; intraclass correlation coefficient; misclassification; EXPOSURE; CHILDREN; VARIABILITY; METABOLITE; BEHAVIOR; COHORT; WOMEN;

D O I：

10.1038/jes.2014.23

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The potential human health effects of bisphenol A (BPA) exposure are a public health concern. In order to design adequately powered epidemiological studies to address potential health effects, data on the reproducibility of BPA concentration in serial urine specimens taken during pregnancy are needed. To provide additional data on the reproducibility of maternal urine specimens, 80 women in the Generation R Study (Rotterdam, The Netherlands) contributed a spot urine specimen at <18, 18-25, and >25 weeks of pregnancy. Reproducibility, estimated by the intraclass correlation coefficient (ICC), was 0.32 (95% confidence interval: 0.18-0.46), and, on a creatinine basis, 0.31 (95% confidence interval: 0.16-0.47). Although the ICC observed in the Generation R Study is slightly higher than previous reproducibility studies of BPA, it nevertheless indicates a high degree of within-person variability that presents challenges for designing well-powered epidemiologic studies.

引用

页码：532 / 536

页数：5

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