Effects of Total Anthraquinones of Polygonum Cuspidatum on the Levels of Insulin, Leptin and C-Peptide in Serum in Diabete Rat Model

To investigate the effect of total anthraquinone of Polygonum cuspidatum (TAPC) in diabete rats which were established by streptozotocin. Method: The diabete rat model was established by injected with streptozotocin, and then randomized into 5 groups. Which were fed with high dosage TAPC group, medium dosage TAPC group, low dosage TAPC group (400mg.kg(-1), 200mg.kg(-1), 100mg.kg(-1)), metformin group (208 mg.kg(-1)) and model group. Control group was set up with healthy normal rats. All the rats were administrated once a day for 30 days. Blood glucose (BG) in the limosis were measured on the 20, 30 day and then rats were sacrificed. The levels of insulin, insulin antibody, leptin, C-peptide in orbital blood were measured. Results: Diabetic model rats successfully. Compared with model group, The high dosage TAPC group can significantly reduce the level of blood suga on 30 day(P<0.01), Can significantly reduce the level of blood suga on 20 day (P<0.05); The medium dosage TAPC group significantly reduce the level of blood suga on 20, 30 day (P<0.01); The medium and low dosage TAPC group significantly increased the level of insulin (P<0.01); Each dosage TAPC group can significantly reduce the level of C-peptide (P<0.01). Conclusion: TAPC has good hypoglycemic effect on the diabete rats established by injection of streptozotocin