Rh(III)-Catalyzed Hydroarylation of Alkyne MIDA Boronates via C-H Activation of Indole Derivatives

被引：31

作者：

Fei, Xiao ^{[1
,2
,3
,4
]}

Li, Chunpu ^{[3
,4
]}

Yu, Xinhong ^{[1
,2
]}

Liu, Hong ^{[3
,4
]}

机构：

[1] East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioengn Reactors, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 11期

基金：

中国国家自然科学基金;

关键词：

DIVERGENT SYNTHESIS; PROPARGYL ALCOHOLS; BOND ACTIVATION; ANNULATION; ACCESS; EFFICIENT; DIFUNCTIONALIZATION; ISOINDOLINONES; PLATFORM; ANALOGS;

D O I：

10.1021/acs.joc.9b00638

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient approach to trans-indolylvinylboronate derivatives has been developed using an Rh-catalyzed hydroarylation of alkyne N-methyliminodiacetic acid boronates via C-H activation. This protocol constitutes a straightforward route for the synthesis of B-containing aza-heterocycles in good yields with excellent functional group tolerance.

引用

页码：6840 / 6850

页数：11

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