Preparation of indoles from o-alkynyltrifluoroacetanilides through the aminopalladation-reductive elimination process

被引：58

作者：

Cacchi, S ^{[1
]}

Fabrizi, G ^{[1
]}

Parisi, LM ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Sostanze Biol Attive, I-00185 Rome, Italy

来源：

SYNTHESIS-STUTTGART | 2004年 / 11期

关键词：

indoles; alkynes; cyclization; palladium; catalysis;

D O I：

10.1055/s-2004.815993

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The functionalized pyrrole nucleus contained in the indole system has been assembled via the palladium-catalyzed reaction of o-alkynyltrifluoroacetanilides with organic halides/triflates or allyl carbonates. In the presence of carbon monoxide, a three-component reaction can take place and indole derivatives incorporating a molecule of carbon monoxide have been obtained.

引用

页码：1889 / 1894

页数：6

共 17 条

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[2] Arcadi A, 2000, SYNLETT, P647
[3] 2-SUBSTITUTED-3-ACYLINDOLES THROUGH THE PALLADIUM-CATALYZED CARBONYLATIVE CYCLIZATION OF 2-ALKYNYLTRIFLUOROACETANILIDES WITH ARYL HALIDES AND VINYL TRIFLATES
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CACCHI, S
CARNICELLI, V
MARINELLI, F
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[7] 12-acylindolo[1,2-c]quinazolines by palladium-catalyzed cyclocarbonylation of o-alkynyltrifluoroacetanilides
Battistuzzi, G
Cacchi, S
Fabrizi, G
Marinelli, F
Parisi, LM
[J]. ORGANIC LETTERS, 2002, 4 (08) : 1355 - 1358
[8] 2-substituted 3-aryl- and 3-heteroarylindoles by the palladium-catalyzed reaction of o-trifluoroacetanilides with aryl bromides and triflates
Cacchi, S
Fabrizi, G
Lamba, D
Marinelli, F
Parisi, LM
[J]. SYNTHESIS-STUTTGART, 2003, (05): : 728 - 734
[9] Cacchi S, 1999, SYNLETT, P620
[10] Cacchi S, 1997, SYNLETT, P1363

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