Giant proteins that move DNA:: bullies of the genomic playground

被引：43
作者：
Cozzarelli, Nicholas R. [1 ]
Cost, Gregory J. [1 ]
Nöllmann, Marcelo [1 ]
Viard, Thierry [1 ]
Stray, James E. [1 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 08期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1982
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
As genetic material DNA is wonderful, but as a macromolecule it is unruly, voluminous and fragile. Without the action of DNA replicases, topoisomerases, helicases, translocases and recombinases, the genome would collapse into a topologically entangled random coil that would be useless to the cell. We discuss the organization, movement and energetics of these proteins that are crucial to the preservation of a molecule that has such beautiful biological but challenging physical properties.
引用
收藏
页码：580 / 588
页数：9
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