Apoptosis-inducing activity of synthetic intermediates of hatichlorine

被引：12

作者：

Itoh, M ^{[1
]}

Kuwahara, J ^{[1
]}

Itoh, K ^{[1
]}

Fukuda, Y ^{[1
]}

Kohya, M ^{[1
]}

Shindo, M ^{[1
]}

Shishido, K ^{[1
]}

机构：

[1] Univ Tokushima, Inst Med Resources, Tokushima 7708505, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(02)00373-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-I) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2069 / 2072

页数：4

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