MDR1 C3435T polymorphism in Mexican patients with breast cancer

被引:11
作者
Macias-Gomez, N. M. [1 ]
Gutierrez-Angulo, M. [2 ]
Leal-Ugarte, E. [3 ]
Ramirez-Reyes, L. [1 ]
Peregrina-Sandoval, J. [4 ]
Meza-Espinoza, J. P. [3 ]
Solano, F. Ramos [5 ]
de la Luz Ayala-Madrigal, M. [6 ]
Telles, F. Santoyo [1 ]
机构
[1] Univ Guadalajara, Ctr Univ Sur, Dept Salud Bienestar, Guzman, Jalisco, Mexico
[2] Univ Guadalajara, Ctr Univ Altos, Tepatitlan De Morelos, Jalisco, Mexico
[3] Univ Autonoma Tamaulipas, Unidad Acad Ciencias Salud & Tecnol, Matamoros, Tamaulipas, Mexico
[4] Univ Guadalajara, Ctr Univ Ciencias Biol & Agropecuarias, Guadalajara 44430, Jalisco, Mexico
[5] CMNO IMSS, Unidad Patol, Guadalajara, Jalisco, Mexico
[6] Univ Guadalajara, Ctr Univ Ciencias Salud, Guadalajara 44430, Jalisco, Mexico
关键词
Breast Cancer; Malignant breast lesions; Fibrocystic changes; P-glycoprotein; MDR1; SINGLE-NUCLEOTIDE POLYMORPHISM; MULTIDRUG-RESISTANCE GENE; P-GLYCOPROTEIN; FUNCTIONAL-SIGNIFICANCE; CHEMOTHERAPY RESPONSE; IRANIAN POPULATION; RISK-FACTORS; EXPRESSION; ASSOCIATION; METAANALYSIS;
D O I
10.4238/2014.July.4.17
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro Medico de Occidente (Mexico) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 paraffin-embedded breast samples with IDBC, 64 samples with FCC, and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52% for the FCC, IDBC, and HG samples, respectively. Significant differences were only found between the FCC and HG samples [odds ratio (OR) = 0.64, 95% confidence interval (CI) = 0.43-0.96; P = 0.032]. The prevalence of the T/T genotype was 8, 13, and 24% for FCC, IDBC, and HG samples, respectively. Again, statistical differences were only found between FCC and HG samples for the T/T genotype (OR = 0.28, 95%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the C3435T polymorphism and clinical-pathological features of the IDBC group. Both the FCC and IDBC groups had a high frequency of the C allele relative to the HG in this sample of women from Western Mexico.
引用
收藏
页码:5018 / 5024
页数:7
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