Dietary enrichment with alpha-linolenic acid during pregnancy attenuates insulin resistance in adult offspring in mice

被引：20

作者：

Hollander, K. S. ^{[1
]}

Brami, C. Tempel ^{[2
]}

Konikoff, F. M. ^{[1
]}

Fainaru, M. ^{[3
]}

Leikin-Frenkel, A. ^{[1
,3
]}

机构：

[1] Tel Aviv Univ, Minerva Ctr Cholesterol, Gallstones Res & Lipid Metab Liver, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, GSW Fac Life Sci, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2014年 / 120卷 / 03期

关键词：

alpha-linolenic acid; dietary enrichment; insulin resistance; pregnancy; STEAROYL-COA DESATURASE-1; FATTY-ACIDS; GENE-EXPRESSION; DEVELOPMENTAL ORIGINS; METABOLIC SYNDROME; LIPID-METABOLISM; MATERNAL DIET; FEMALE MICE; MECHANISMS; OBESITY;

D O I：

10.3109/13813455.2014.940352

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objective: Our objective was to test the contribution of dietary enrichment in essential or saturated fatty acids, in normocaloric diets, on the lipid accumulation and insulin resistance in the adult offspring in a C57Bl6/J mice model. Methods: Pregnant mothers were fed normocaloric diets containing 6% fat enriched in essential fatty acids (EFA): alpha-linolenic (ALA-18:3, n-3), linoleic (LA-18:2, n-6), or saturated fatty acids (SFA). After a washing-out period with regular diet, the offspring received a high-fat diet before euthanization. Results: Adult mice fed maternal ALA showed lower body weight gain and lower liver fat accumulation, lower HOMA index and lower stearoyl-CoA desaturase (SCD1) activity than those fed maternal SFA. Conclusion: The results observed using this novel model suggest that ALA in maternal diet may have the potential to inhibit insulin resistance in adult offspring.

引用

页码：99 / 111

页数：13

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