8-hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs)

被引：27

作者：

Zeng, He-Ping ^{[1
]}

Wang, Ting-Ting

Ouyang, Xin-Hua

Zhou, Ya-Dong

Jing, Hui-Lian

Yuan, Guo-Zan

Chen, Dong-Feng

Du, Shao-Hui

Li, Hui

Zhou, Jian-Hong

机构：

[1] S China Univ Technol, Sch Chem, Inst Funct Mol, Guangzhou 510641, Peoples R China

[2] Guangzhou Univ Trad Chinese Med, Guangzhou 510405, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 16期

基金：

中国国家自然科学基金;

关键词：

rat mesenchymal stem cells (rMSCs); proliferation; 8-hydroxyquinoline derivatives;

D O I：

10.1016/j.bmc.2006.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 8-hydroxyquinoline derivatives with different substituted groups at 2- or 5-position have been synthesized and characterized. Their effects on the proliferation of the rat marrow-derived mesenchymal stem cells (rMSCs) have been evaluated by MTT assay and flow cytometry. We also analyzed the ability of these compounds to regulate the proliferation of rMSCs and the relationship with the structures of 8-hydroxyquinoline. Compounds 8-11, in which, the vinyl-substituents are on the 2-position of 8-hydroxyquinoline, appear to be able to induce the proliferation of rMSCs. These results show that compounds 8-11 provide a kind of new substances for regulating the proliferation of rMSCs. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5446 / 5450

页数：5

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